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个人简介
Prof. Parren is dedicated to translate antibody biology and immunotherapy knowledge into innovative therapeutics and technologies. He has a passion for investigating and understanding structure-function relationships and translating the knowledge gained into immunotherapy applications and drug development. He is an inventor of the therapeutic antibodies ofatumumab (Arzerra, Kesimpta) daratumumab (DARZALEX), teprotumumab (Tepezza), tisotumab vedotin (Tivdak) en amivantamab (Rybrevant). Ofatumumab was approved in 2009 for the treatment of Chronic Lymphocytic Leukemia and in 2020 in a subcutaneous formulation for Multiple Sclerosis. Ofatumumab received the Dutch Galenus Prize in 2011 for most innovative new medicine. Ofatumumab (Arzerra) has, for the treatment of cancer, since been transitioned to compassionate use and oncology access programs. Daratumumab was first approved in 2015 for the treatment of Multiple Myeloma. Teprotumumab was approved for the treatment of Active Thyroid Eye Disease (Graves’ orbitopathy in 2020. Tisotumab vedotin (an antibody-drug conjugate) and amivantamab (an EGFR-cMet bispecific antibody) were approved in 2021 by FDA for the treatment of recurrent or metastatic cervical cancer and for metastatic NSCLC with EGFR exon 20 insertion, respectively. Paul Parren further invented and developed several clinically translated technologies aimed at improving antibody therapy, including bispecific antibodies and effector function-enhanced antibodies (DuoBody and HexaBody platforms). The first bispecific antibody product based on the DuoBody technology obtained regulatory approval in 2021. His work has thus far directly led to four therapeutic antibodies that received FDA Breakthrough Therapy designation and ten further therapeutic antibodies in various formats currently in clinical development for the treatment of cancer and Parkinson’s disease.
研究兴趣
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CANCER GENE THERAPYno. 1 (2024): 58-68
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Bart E.C.G. de Goeij, Tom Vink, Hendrik ten Napel,Esther C.W. Breij,David Satijn,Richard Wubbolts, David Miao,Paul W.H.I. Parren
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Sheri L. Moores,Mark L. Chiu,Barbara S. Bushey,Kristen Chevalier,Leopoldo Luistro, Keri Dorn,Randall J. Brezski, Peter Haytko,Thomas Kelly,Sheng-Jiun Wu, Pauline L. Martin,Joost Neijssen,
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Roeland Lameris,Jurjen M Ruben,Victoria Iglesias-Guimarais, Milon de Jong, Myrthe Veth,Fleur S van de Bovenkamp,Iris de Weerdt, Arnon P Kater,Sonja Zweegman,Sjeng Horbach,Thilo Riedl,Benjamin Winograd,
Cell reports. Medicineno. 3 (2023): 100961-100961
Sheri L. Moores,Mark L. Chiu,Barbara S. Bushey,Kristen Chevalier,Leopoldo Luistro, Keri Dorn,Randall J. Brezski, Peter Haytko,Thomas Kelly,Sheng-Jiun Wu, Pauline L. Martin,Joost Neijssen,
crossref(2023)
crossref(2023)
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