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The Protein Expression Laboratory (PEL) was established in 1990 in the Office of the Director by the Deputy Director for Intramural Research with the mission to produce and characterize human immunodeficiency virus (HIV-1) proteins for the intramural research effort. Extensive collaborations with NIH investigators have led to numerous publications and significant advances. In 1996, the PEL was transferred to the NIAMS, leading to an extended and highly productive collaboration with the Laboratory of Structural Biology Research (LSBR/NIAMS) headed by Dr. Alasdair Steven, a world leader in the field of cryo-electron microscopy.
Individuals with HIV-1 are frequently co-infected with hepatitis B virus (HBV) due to similar routes of transmission. Chronic viral hepatitis in recent years has become one of the most frequent causes of hospital admissions and mortality among HIV-infected patients. In this way, chronic HBV behaves as an opportunistic infection in the context of HIV infection. The management of HIV-positive individuals should include prevention, regular screening for HBV infection, and the administration of anti-HBV therapy to co-infected patients. The long-term efficacy and safety of combination treatment with agents that exert activity against both viruses also warrant investigation.
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bioRxiv (Cold Spring Harbor Laboratory) (2021)
bioRxiv : the preprint server for biologyno. 4 (2021): e0209421-e0209421
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