The general interest of my laboratory is the cellular and molecular biology of the nervous system. Our principle work focuses on degeneration of the motor system. Previously we identified a gene mutation responsible for a rare form of Amyotrophic Lateral Sclerosis. Using in vitro model systems and genetically modified animals we and our collaborators are exploiting this, and other genetic information to study more generally the processes of neurodegeneration. We also contribute to experiments on synaptic physiology, with particular focus on plasticity, intellectual disability and epilepsy.