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Paul Schimmel’s research interests have focused on aminoacyl tRNA synthetases — an ancient and universal set of essential enzymes. His laboratory has worked on a universal mechanism for correcting errors in the interpretation of genetic information, and went on to show how this mechanism is essential for maintaining cellular homeostasis and preventing serious pathologies and disease. His laboratory also discovered what others refer to as a ‘tRNA synthetase-directed primordial’ or ‘second’ genetic code, which was eventually incorporated into the modern code. In a separate line of research published back in 1983, Schimmel developed the concept of what are now known as ESTs (expressed sequence tags), and the strategy of shotgun sequencing — approaches that were adopted into the human genome project several years later. Lastly, his laboratory connected synthetases to disease and, most recently, they reported the structural and functional metamorphosis of these proteins, whereby they are repurposed with novel activities, both inside and outside the cell, in a variety of cell signaling pathways. Paul Schimmel is no longer accepting students.
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MOLECULAR CELLno. 22 (2023): 3953-3971
Bastiaan de Potter,Ingrid Vallee,Noelia Camacho,Luís Filipe Costa Póvoas,Aureliano Bonsembiante, Alba Pons I Pons, Ulrich Eckhard, Francesc-Xavier Gomis-Rüth,Xiang-Lei Yang,Paul Schimmel,Bernhard Kuhle,Lluís Ribas de Pouplana
Nucleic acids researchno. 18 (2023): 10001-10010
Nature Cell Biologyno. 6 (2021): 676-676
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