Paul Matthews, MA (Oxon), DPhil, MD (Stanford), FRCP, FMedSci is the Director of the Rosalind Franklin Institute on the Harwell Science and Innovation Campus, Edmond and Lily Safra Professor of Translational Neuroscience and Therapeutics in the Department of Brain Sciences at Imperial College London and a Group Leader in the UK Dementia Research Institute at Imperial. Since 2009 he has been on the Steering Committee of UK Biobank and has chaired the Imaging Enhancement Working Group, which has supported UK Biobank in creating the world’s largest imaging epidemiological dataset. Since 2023, he also has been co-chair of the UK Biobank Dementia Working Group.
Paul’s current research addresses neuroinflammatory mechanisms of neurodegeneration with a focus on Alzheimer’s disease (AD) and multiple sclerosis. He has been addressing these using a wide range of epidemiological, MRI and PET imaging and molecular ‘omics tools. This now is leading to new translational clinical studies concerning the role of mitochondrial and vascular dysfunction in accelerating the progression of AD and in assessing a novel brain immunomodulatory target.