基本信息
浏览量:166
职业迁徙
个人简介
My group is focused primarily on two projects: studies of the association of characteristics of tumor reactive T cells administered to patients and clinical response and the generation of high affinity TCRs for the treatment of patients with cancer. Recent studies have focused on the identification of mutated antigens recognized by T cells derived from patients with a variety of cancers including melanoma, colon, breast, ovarian and lung cancer by carrying out high-throughput sequencing of tumor DNA and RNA. The results have demonstrated that more mutation reactive T cells can be identified in more than 80% of patients with these common cancers. In addition, treatment of patients with enriched populations of mutation reactive T cells have led to substantial tumor regressions in two patients with gastrointestinal cancers. Further studies will hopefully lead to the development of highly effective and broadly applicable immunotherapies for the treatment of patients with these solid cancers.
研究兴趣
论文共 244 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Journal for ImmunoTherapy of Cancerno. 5 (2023): e006264-e006264
引用0浏览0引用
0
0
crossref(2023)
CANCER CELLno. 12 (2023): 2154-2165.e5
Cancer cellno. 4 (2023): 646-648
crossref(2023)
Journal for immunotherapy of cancerno. 5 (2023)
引用0浏览0WOS引用
0
0
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn