Paul Bowness - Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford

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Bio

Current Research Projects

Professor Bowness leads a group investigating the Immunology of Ankylosing Spondylitis and he also has active research interests in the immunology of inflammatory arthritis including:

The natural role of HLA-B27 in the immune system
The role of HLA-B27 homodimers in disease pathogenesis

Research Interests

Papers共 289 篇Author StatisticsCo-AuthorSimilar Experts

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CD4+ Tissue-Resident Memory Th17 Cells Are a Major Source of IL-17A in Spondyloarthritis Synovial Tissue

Feng Liu,Hui Shi,Jason D Turner, Rachel Anscombe, Jiaqi Li, Takuya Sekine,Ariane Hammitzsch, Devika Agarwal, Christopher Mahony,Jiewei Chen, Ben Kendrick,Dajiang Du,Qiang Tong,Lihua Duan, Kyla Dooley,Hai Fang,Ilya Korsunsky, Roopa Madhu, Adam P Cribbs, Cartography Consortium,Matthias Friedrich, Brian D Marsden, Yi-Ling Chen, Graham Ogg, Anna Adams, Warner Chen, Steven Leonardo, Fiona E McCann, Christopher D Buckley,Terence Rooney, Thomas Freeman, Holm H Uhlig,Calliope Dendrou,Adam Croft,Andrew Filer,Paul Bowness,Liye Chen

Annals of the rheumatic diseases (2025)

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Inflammatory Disease Microbiomes Share a Functional Pathogenicity Predicted by C-reactive Protein

Graham J Britton,Ilaria Mogno,Alice Chen-Liaw,Tamar Plitt,Drew Helmus,Gerold Bongers,India Brough, Paula Colmenero, Lilian H Lam, Samuel J Bullers, Frank Penkava, Pamela Reyes-Mercedes,Jonathan Braun, Jonathan P Jacobs, A Nicole Desch,Dirk Gevers, Sheri Simmons,Andrew Filer, Peter C Taylor,Paul Bowness,Curtis Huttenhower,Dan Littman,Marla C Dubinsky,Karim Raza,Stephanie K Tankou,Jeremiah J Faith

bioRxiv the preprint server for biology (2025)

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Elevated Type-17 Cytokines Are Present in Axial Spondyloarthritis Stool

India Brough,Kelsey Thompson, Ciara Latore,Frank Penkava, Chelsea Regan,Claire Pearson,Hui Shi,Anna Ridley,Davide Simone,Lilian Lam,Samuel Bullers, Caroline Moussa, Rachel Feeney, Inflammatory Arthritis Microbiome Consortium (IAMC) Investigators Group,Mohammed H Al-Mossawi,Fiona Powrie,Stephen Young,Curtis Huttenhower,Paul Bowness

Discovery Immunology (2024)

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THE GHENT SPA ORATION: 50 YEARS OF HLA-B27

P. Bowness

CLINICAL AND EXPERIMENTAL RHEUMATOLOGYno. 9 (2024): 3-3

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HLA-B27 and Spondyloarthritis: at the Crossroads of Innate and Adaptive Immunity

Fatemeh Navid,Liye Chen,Paul Bowness,Robert A. Colbert

Nature Reviews Rheumatologyno. 2 (2024): 77-87

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Increased Interleukin-26 in the Peripheral Joints of Patients with Axial Spondyloarthritis and Psoriatic Arthritis, Co-Localizing with CD68-positive Synoviocytes

Ariane Hammitzsch, Andreas Ossadnik,Quirin Bachmann, Helga Merwald-Fraenk,Georg Lorenz,Matthias Witt, Franziska Wiesent, Heinrich Muehlhofer,Davide Simone,Paul Bowness,Uwe Heemann,Martin Arbogast,Philipp Moog,Christoph Schmaderer

FRONTIERS IN IMMUNOLOGY (2024)

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TISSUE RESIDENT MEMORY TH17 (TRM17) CELLS ARE THE PREDOMINANT SOURCE OF INTERLEUKIN (IL)-17 IN SPONDYLOARTHRITIS, PRODUCE IL-17 INDEPENDENT OF IL-23 AND ARE EPIGENETICALLY REGULATED BY BROMODOMAIN CONTAINING 1 (BRD1)

F. Liu, H. Shi, J. Turner, R. Anscombe, D. Agarwa, C. Mahony, W. Chen,B. Kendrick, D. Du, Q. Tong, L. Duan, C. Dendrou,C. Buckley,A. Croft,A. Filer,P. Bowness, L. Chen

CLINICAL AND EXPERIMENTAL RHEUMATOLOGYno. 9 (2024): 10-10

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Granulocyte-macrophage Colony-Stimulating Factor Neutralisation in Patients with Axial Spondyloarthritis in the UK (NAMASTE): a Randomised, Double-Blind, Placebo-Controlled, Phase 2 Trial

Claudia Worth,M. Hussein Al-Mossawi, Joanne Macdonald,Benjamin A. Fisher,Antoni Chan,Raj Sengupta,Jonathan Packham,Karl Gaffney,Nicola Gullick,Jonathan A. Cook, Tim H. Corn,James Teh,Pedro M. Machado,Peter C. Taylor,Paul Bowness

LANCET RHEUMATOLOGYno. 8 (2024): e537-e545

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Mucosal Signatures of Pathogenic T Cells in HLA-B*27+ Anterior Uveitis and Axial Spondyloarthritis

Michael A. Paley,Xinbo Yang,Lynn M. Hassman,Frank Penkava,Lee I. Garner,Grace L. Paley,Nicole Linskey, Ryan Agnew, Paulo Henrique Arantes de Faria,Annie Feng, Sophia Y. Li,Davide Simone,Elisha D. O. Roberson,Philip A. Ruzycki,Ekaterina Esaulova,Jennifer Laurent, Lacey Feigl-Lenzen,Luke E. Springer,Chang Liu,Geraldine M. Gillespie,Paul Bowness,K. Christopher Garcia,Wayne M. Yokoyama

JCI Insight (2024)

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The Tissue-Resident Memory Th17 (TRM17) Cells, the Predominant Source of Interleukin (IL)-17 in Inflammatory Arthritis, is Largely IL-23 Independent in Their Effector Function and Epigenetically Regulated by Bromodomain Containing 1 (BRD1)

Feng Liu, Rachel Anscombe,Hui Shi,Paul Bowness,Liye Chen

EUROPEAN JOURNAL OF IMMUNOLOGY (2024): 114-114

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