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On 11 February 1958 he developed haloperidol, a major breakthrough in the treatment of schizophrenia. Working with his team, he developed the fentanyl family of drugs and a number of anesthetic agents, including droperidol and etomidate. One of the anti-diarrheal drugs he developed, diphenoxylate (Lomotil), was used in the Apollo program.
In 1959, Janssen synthesized the potent opioid fentanyl based on SAR studies of meperidine. In the 1970s, he would improve upon the potency of fentanyl with the synthesis of Carfentanil.
Altogether Janssen and his cadre of scientists discovered more than eighty new medications, four of which are on the WHO list of essential medicines.
In 1959, Janssen synthesized the potent opioid fentanyl based on SAR studies of meperidine. In the 1970s, he would improve upon the potency of fentanyl with the synthesis of Carfentanil.
Altogether Janssen and his cadre of scientists discovered more than eighty new medications, four of which are on the WHO list of essential medicines.
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论文共 81 篇作者统计合作学者相似作者
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Paulus Joannes Lewi,Paul A J Janssen,Marc Rene De Jonge, Lucien Maria Henricus Koymans,Hendrik Maarten Vinkers, Frederik Frans Desire Daeyaert,Jan Heeres,Ruben Leenders, Georges Joseph Cornelius Hoomaert,Amuri Kilonda, Donald William Ludovici
mag(2009)
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Cardiovascular Drug Reviewsno. 1 (2007): 1-56
Georges Hoornaert,Amuri Kilonda,Jan Heeres, Paulus Joannes Lewi,Jonge Marc Rene De, Frederik Frans Desire Daeyaert,Hendrik Maarten Vinkers,Lucien Maria Henricus Koymans,Paul A J Janssen
mag(2005)
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