基本信息
浏览量:188
职业迁徙
个人简介
Research
Patrik Rorsman’s research focuses on insufficient insulin secretion combined with hypersecretion of glucagon result in the metabolic dysregulation linked with clinical diabetes.
He has published more than 220 papers dealing with the function of the pancreatic islet cells and has performed pioneering studies on the cellular and molecular regulation of pancreatic islet hormone secretion, the mechanisms that underlie the ability of the different types of islet cell to sense changes in the body’s metabolic state and adjust the release of insulin and glucagon to the functional requirements.
His research aims to explain the fundamental mechanisms regulating insulin and glucagon secretion. The work involves a combination of techniques to study secretion at the molecular, cellular and systemic levels. This requires sophisticated methodology to record the minute electrical currents flowing across biological membranes and secretion in individual cells at millisecond resolution. Optical techniques that allow monitoring the movements of single secretory granules within the cell prior and during secretion are also used. This work has led to an improved understanding of the normal regulation of insulin and glucagon secretion. This provides a knowledge base needed to define the defects associated with diabetes and for the development of novel therapeutic interventions.
His most recent work focuses on the mechanisms by which weight reduction surgery leads to rapid resolution of diabetes. These studies have highlighted an important role of the gut peptide PYY as the mediator of the effects. It is hoped that these observations ultimately can be translated into a non-surgical treatment of type-2 diabetes.
Patrik Rorsman’s research focuses on insufficient insulin secretion combined with hypersecretion of glucagon result in the metabolic dysregulation linked with clinical diabetes.
He has published more than 220 papers dealing with the function of the pancreatic islet cells and has performed pioneering studies on the cellular and molecular regulation of pancreatic islet hormone secretion, the mechanisms that underlie the ability of the different types of islet cell to sense changes in the body’s metabolic state and adjust the release of insulin and glucagon to the functional requirements.
His research aims to explain the fundamental mechanisms regulating insulin and glucagon secretion. The work involves a combination of techniques to study secretion at the molecular, cellular and systemic levels. This requires sophisticated methodology to record the minute electrical currents flowing across biological membranes and secretion in individual cells at millisecond resolution. Optical techniques that allow monitoring the movements of single secretory granules within the cell prior and during secretion are also used. This work has led to an improved understanding of the normal regulation of insulin and glucagon secretion. This provides a knowledge base needed to define the defects associated with diabetes and for the development of novel therapeutic interventions.
His most recent work focuses on the mechanisms by which weight reduction surgery leads to rapid resolution of diabetes. These studies have highlighted an important role of the gut peptide PYY as the mediator of the effects. It is hoped that these observations ultimately can be translated into a non-surgical treatment of type-2 diabetes.
研究兴趣
论文共 560 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Nikhil R. Gandasi,Rui Gao, Lakshmi Kothegala,Abigail Pearce, Cristiano Santos,Samuel Acreman,Davide Basco,Anna Benrick,Margarita V. Chibalina,Anne Clark,Claudia Guida,Matthew Harris,
Manon Jaffredo,Nicole A.J. Krentz, Benoite Champon, Claire Duff, Sameena Nawaz,Nicola L. Beer,Christian Honoré,Anne Clark,Patrik Rorsman,Jochen Lang,Anna L. Gloyn,Matthieu Raoux,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv : the preprint server for biology (2023)
引用0浏览0WOS引用
0
0
DIABETESno. Supplement_1 (2023)
引用0浏览0引用
0
0
Sara M. Willems, Natasha Hui Jin Ng, Juan Carlos Delgado Fernández,Rebecca S. Fine,Eleanor Wheeler,Jennifer Wessel,Hidetoshi Kitajima,Gaëlle Marenne,Xueling Sim, Hanieh Yaghootkar,Shuai Wang,Sai Chen,
Wellcome open research (2023): 483-483
引用0浏览0引用
0
0
HORMONE RESEARCH IN PAEDIATRICS (2023): 13-14
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn