基本信息
浏览量:4
职业迁徙
个人简介
My career has been dedicated to research on the genetics of cancer, with emphasis on inherited endocrine tumors and discovery of cancer susceptibility genes (including PTEN, SDHB, KIF1B, EPAS1/HIF2A, TMEM127, etc). This work has had both translational and biological impact. On the translational level, our studies helped define paradigms for genetic testing, patient surveillance, and innovative therapeutic modeling, especially in the area of pheochromocytomas and paragangliomas. Our integrative genomics and signal transduction work uncovered links between energy metabolism, hypoxia, endosome/lysosomal signals and cancer susceptibility. In parallel to the ongoing gene discovery efforts through our patient sample repository (NCT03160274), current lines of investigation in my laboratory explore: a) the function of transmembrane protein TMEM127 tumor suppressor as a nutrient responsive lysosomal component and regulator of insulin sensitivity in vivo, b) epigenetic modulation by SDH and HIF mutations, and c) the epistatic interaction between in vivo hypoxia and HIF mutation (cyanotic congenital heart disease and paraganglioma, NEJM, 2018).
研究兴趣
论文共 91 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Xufeng Chen,Qiao Lu,Hua Zhou,Jia Liu,Bettina Nadorp,Audrey Lasry,Zhengxi Sun, Baoling Lai,Gergely Rona, Jiangyan Zhang,Michael Cammer,Kun Wang,
Qiao Lu,Xufeng Chen,Hua Zhou,Jia Liu,Bettina Nadorp,Audrey Lasry,Zhengxi Sun, Jiangyan Zhang,Michael Cammer,Kun Wang,Zoe Ciantra, Jia You,
Journal of Immunologyno. 1 (2023): 89.12-89.12
Cancer Researchno. 7_Supplement (2023): 195-195
引用0浏览0引用
0
0
Nature Communicationsno. 1 (2023): 123-123
Patricia L.M. Dahia,Ke Hao, John Rogus, Christian Colin, Miguel A.G. Pujana, Ken Ross, Danielle Magoffin,Neil Aronin,Alberto Cascon, César Y. Hayashida,Cheng Li,Sérgio P.A. Toledo,
crossref(2023)
Zhijun Qiu, Jihane Khalife,An-Ping Lin,Purushoth Ethiraj,Carine Jaafar,Lilly Chiou, Gabriela Huelgas-Morales, Sadia Aslam,Shailee Arya,Yogesh K Gupta,Patricia L M Dahia,Ricardo C T Aguiar
bioRxiv : the preprint server for biology (2023)
引用0浏览0WOS引用
0
0
Qianjin Guo,Zi-Ming Cheng,Hector Gonzalez-Cantú, Matthew Rotondi, Gabriela Huelgas-Morales,Purushoth Ethiraj,Zhijun Qiu, Jonathan Lefkowitz, Wan Song,Bethany N Landry, Hector Lopez,Cynthia M Estrada-Zuniga,
Cell reportsno. 9 (2023): 113070-113070
Cynthia M Estrada-Zuniga,Zi-Ming Cheng,Purushoth Ethiraj,Qianjin Guo,Hector Gonzalez-Cantú, Elaina Adderley, Hector Lopez,Bethany N Landry,Abir Zainal,Neil Aronin,Yanli Ding,Xiaojing Wang,
Cell reports. Medicineno. 7 (2022): 100686-100686
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn