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Currently there is a gap of knowledge in that we have not been able to identify a reliable form of preventing dentin and bone loss in various physiological and pathological scenarios. My long-term goals are to unveil novel mechanisms of protecting such mineralized tissues, characterize new effective agents and ultimately bring these agents to clinical practice. My research studies have concentrated in understanding collagen biochemistry and tissue mechanical properties link; promotion of mineralization (re-mineralization) in dentin and bone and, more recently, focused in the role of the proteoglycan biglycan in promotion of craniofacial bone regeneration through modulation of bone morphogenetic protein function. Other biological and translational experiments are in development to promote dentin formation. Another area of interest is on integrative medicine where I seek to understand how natural compounds (phytochemicals) act on cell behavior, extracellular matrix quality and mineralization as well as their effect on oral diseases development such as caries and periodontal disease.
研究兴趣
论文共 52 篇作者统计合作学者相似作者
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Patricia A. Miguez,Vinícius de Paiva Gonçalves, Marta L. Musskopf, Angeliz Rivera-Concepcion, Skylar McGaughey,Christina Yu,Dong Joon Lee, Stephen A. Tuin, Aya Ali
Journal of clinical periodontologyno. 5 (2024): 610-630
CELL DEATH AND DIFFERENTIATIONno. 3 (2023): 855-855
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PERIODONTOLOGY 2000 (2023)
Vinícius de Paiva Gonçalves,Marta Liliana Musskopf, Angeliz Rivera-Concepcion, Christina Yu,Sing Wai Wong,Stephen A Tuin,Yizu Jiao,Cristiano Susin,Luís Carlos Spolidorio,Patricia Almeida Miguez
Patricia A Miguez,Stephen A Tuin,Adam G Robinson,Joyce Belcher, Prapaporn Jongwattanapisan, Kimberly Perley, Vinicius de Paiva Gonҫalves,Arash Hanifi,Nancy Pleshko,Elisabeth R Barton
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