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Our research interests focus on the development of nanoparticles for use as adjuvants in prophylactic and therapeutic vaccines and as tools for studying the key biological pathways leading to the induction of protective immunity. In particular, we are developing emulsion based adjuvants to drive more robust, durable, and broadly protective immunity towards the influenza virus. Current influenza virus vaccines offer suboptimal protection due to their low immunogenicity, particularly in immunocompromised populations, and to the limited cross-subtype protection they confer. The size and physicochemical properties of emulsion based adjuvants mimic several of the characteristics of viral and bacterial pathogens, allowing them to more effectively activate the immune pathways involved in natural infection as compared to traditional adjuvants. Using these adjuvants, we are also studying how they be harnessed to redirect the immune system in other disease models.
研究兴趣
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Gabriel Laghlali, Matthew J Wiest, Dilara Karadag,Prajakta Warang, Jessica J O'Konek,Lauren A Chang,Seokchan Park,Mohammad Farazuddin, Jeffrey J Landers,Katarzyna W Janczak,Adolfo García-Sastre,James R Baker,
bioRxiv : the preprint server for biology (2024)
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University of Michigan Undergraduate Research Journalno. 0 (2023)
Kelsea Chen, Kelly O'Shea,Charles Schuler,Jesse Chen,Jonathan Troost,Pamela Wong, Daniel O'Shea,Westley Peng,Carmen Gherasim,David Manthei,Riccardo Valdez,James Baldwin,
Pamela T. Wong, Sonia Jangra, Jeffrey J. Landers, Gabriel Laghlali, Raveen Rathnasinghe, Jessica J. O'Konek,Katarzyna W. Janczak, Adolfo Garcia-Sastre,James R. Baker, Michael Schotsaert
Journal of Immunologyno. 1 (2023): 159.23-159.23
Research Square (Research Square) (2023)
Daniel O’Shea,Charles Schuler,Jesse Chen,Jonathan Troost,Pamela Wong,Kelsea Chen,Westley Peng,Carmen Gherasim,David Manthei,Riccardo Valdez,James Baldwin, Kelly O'Shea,
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