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职业迁徙
个人简介
My lab has focused on understanding the mechanisms that determine whether T cells are activated or tolerized in vivo. We use a variety of transgenic and gene knock out mouse models to evaluate the molecular pathways that govern T cell fate. In particular, we examine how to promote T cell responses to tissues, with a goal to understand and control autoimmune and anti-tumor immune responses.
Our recent studies have examined novel ways that dendritic cells are programmed to influence T cell function in vivo. In addition we are focussed on how the tissue or tumor microenvironment can have a significant impact on T cell responses.
Importantly, my interests have also expanded to establishing an immune therapy platform. My group has developed the ability to grow tumor infiltrating T cells and characterize their properties. We have also coordinated clinical trials and are building towards a comprehensive program in immune therapy.
Our recent studies have examined novel ways that dendritic cells are programmed to influence T cell function in vivo. In addition we are focussed on how the tissue or tumor microenvironment can have a significant impact on T cell responses.
Importantly, my interests have also expanded to establishing an immune therapy platform. My group has developed the ability to grow tumor infiltrating T cells and characterize their properties. We have also coordinated clinical trials and are building towards a comprehensive program in immune therapy.
研究兴趣
论文共 271 篇作者统计合作学者相似作者
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Nature Communicationsno. 1 (2024): 1-11
CANCER RESEARCHno. 7 (2023)
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Samuel D. Saibil,Michael St. Paul, Robert C. Laister,Carlos R. Garcia-Batres,Kavita Israni-Winger,Alisha R. Elford, Natasha Grimshaw, Céline Robert-Tissot,Dominic G. Roy,Russell G. Jones,Linh T. Nguyen,Pamela S. Ohashi
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Samuel D. Saibil,Michael St. Paul, Robert C. Laister,Carlos R. Garcia-Batres,Kavita Israni-Winger,Alisha R. Elford, Natasha Grimshaw, Céline Robert-Tissot,Dominic G. Roy,Russell G. Jones,Linh T. Nguyen,Pamela S. Ohashi
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