Pamela J Shaw
教授
Department of Neuroscience
The Medical School, The University of Sheffield;Cross-Faculty Flagship Neuroscience Institute, University of Sheffield;NIHR Biomedical Research Centre Translational Neuroscience for Chronic Neurological Disorders;Sheffield Care and Research Centre for Motor Neuron Disorders;Sheffield Institute for Translational Neuroscience
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基本信息
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个人简介
Professor Shaw is a Clinician Scientist in Neurology, an NIHR Senior Investigator and formerly a Wellcome Senior Clinical Fellow. Supported by long-term programme funding from the Wellcome Trust, she has since 1991 led a major multidisciplinary programme of research investigating genetic, molecular and neurochemical factors underlying neurodegenerative disorders of the human motor system.
Her team use robust cellular and in vivo models of neurodegeneration and correlate key findings with disease related changes in the human nervous system. Significant research achievements include:
Identification of cell specific features of motor neurons which underlie susceptibility to neurodegeneration.
Understanding the cellular pathways of motor neuron injury in the presence of mutant SOD1 using a combination of cell biology, proteomics and gene expression profiling.
Identifying the different subtypes of motor neuron disease (MND) based on genetics and molecular pathology.
Development of new small molecule and gene therapy candidate treatments for patients using staged screening programmes in cellular and other experimental model systems.
Promoting the introduction of one neuroprotective drug for MND into clinical practice – riluzole.
Establishing the role of non-invasive ventilation (NIV) in improving the quality of life and prolonging survival of MND patients.
Professor Shaw’s research is currently funded by the Medical Research Council, NIHR, the Motor Neurone Disease Association, the European Union and biotechnology & pharmaceutical industry partners. Since 1983 she has generated more than £82m in research income.
研究兴趣
论文共 574 篇作者统计合作学者相似作者
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Scott P Allen, Afnan Al Sultan, Elaine Kabucho Kibirige, Erin Tonkiss, Keaton J Hamer,Lydia M Castelli,Ya-Hui Lin, Sarah Roscoe, Nikolaos Stefanidis,Richard J Mead,J Robin Highley,Johnathan Cooper-Knock,
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Frontiers in cellular neuroscience (2023): 1112405
JOURNAL OF RAMAN SPECTROSCOPYno. 3 (2023): 258-268
medrxiv(2023)
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Muscle & nerveno. 4 (2023): 464-470
Peter J. Richardson,Daniel P. Smith,Alex de Giorgio, Xenia Snetkov, Joshua Almond-Thynne, Sara Cronin,Richard J. Mead,Christopher J. McDermott,Pamela J. Shaw
Translational Neurodegenerationno. 1 (2023): 47-47
Pilot and feasibility studiesno. 1 (2023): 116-116
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SEXUALLY TRANSMITTED INFECTIONSno. SUPPL_1 (2023): A81-A82
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