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Medicinal chemistry and molecular pharmacology of peptide hormones and neurotrnsmitters. Determination of structure-activity relationships of biologically active peptides using an interdisciplinary approach at the interface of chemistry and biology. A major focus is on opioid peptides as starting structures for the development of novel pharmacological tools and of analgesics devoid of the side effects of currently available opiate analgesics. Another research project concerns the development of a new class of mitochondria-targeted antioxidant peptides (SS-peptides) with therapeutic potential for the treatment of diseases associated with oxidative stress.
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Chemical biology & drug designno. 4 (2022): 1012-1018
Tony L Yaksh,Kelly A Eddinger,Shinichi Kokubu,Zhenping Wang,Anna DiNardo,Roshni Ramachandran, Yuelian Zhu, Yajun He, Fieke Weren,Daphne Quang,Shelle A Malkmus,Katherine Lansu,
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