Between 1976 and 1982, before the era of interventional cardiology, Professor Serruys established the methodology of quantitative coronary angiography with the bioengineering group within EMC. In 1980 the balloon angioplasty was introduced at the Thorax Centre, and Professor Serruys was scientifically challenged and tried to elucidate the phenomenon of restenosis post angioplasty in a multidisciplinary approach. In those days, Professor Serruys developed his world-wide networks with various experts to unravel the problem of restenosis. After multiple unsuccessful pharmacological trials to control restenosis phenomenon, his scientific focus was shifted to mechanical device engineering such as stenting. In 1986 he introduced this technique in patients in the Netherlands. Using the latest scientific and experimental knowledge in the field of molecular biology of neointimal inhibition, Professor Serruys and Eduardo Sousa in Brazil introduced the use of drug-eluting stent for the first time in the world, this was in 1999. Professor Serruys revolutionized the field of interventional cardiology by drastically abating the restenosis rate post intervention; however, the implantation of permanent metallic prosthesis was viewed as a major drawback in the treatment of coronary artery stenosis. Therefore in 2006 Professor Serruys introduced worldwide the use of fully biodegradable drug-eluting scaffolds that eliminated the presence of a permanent metallic foreign body in the coronary circulation. In the next decade, Professor Serruys will dedicate his scientific and clinical career to re- revolutionize the field of interventional cardiology by altering the atherosclerotic process and the process through local percutaneous treatment.