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The analysis of the T cell responses of melanoma patients vaccinated against tumor antigens has led to consider the possibility that the limiting factor for therapeutic success is not the intensity of the anti-vaccine response but the degree of anergy presented by intratumoral lymphocytes. We try to understand why tumor-infiltrating lymphocytes are unable to kill tumor cells, and to find strategies to overcome this blockage. We have discovered a new type of anergy of human tumor-infiltrating lymphocytes, due to the presence of galectin-3, a lectin abundant in tumors, as it is corrected by galectin antagonists. We are further analyzing the mechanisms by which galectin antagonists reverse the impaired function and we look for agents that correct this function. A clinical trial combining anti-tumoral therapeutic vaccination and injection of galectin antagonists was launched in 2013 in clinical centers close to the de Duve Institute.
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论文共 273 篇作者统计合作学者相似作者
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Nathalie Demotte,Grégoire Wieërs,Patrick Van Der Smissen,Muriel Moser,Christopher Schmidt,Kris Thielemans, Jean-Luc Squifflet,Birgit Weynand,Javier Carrasco, Christophe Lurquin,Pierre J. Courtoy,Pierre van der Bruggen
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Nathalie Demotte,Grégoire Wieërs,Patrick Van Der Smissen,Muriel Moser,Christopher Schmidt,Kris Thielemans, Jean-Luc Squifflet,Birgit Weynand,Javier Carrasco, Christophe Lurquin,Pierre J. Courtoy,Pierre van der Bruggen
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FRONTIERS IN IMMUNOLOGY (2023): 1308539-1308539
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Guido Leoni, Anna Morena D'Alise,Gabriella Cotugno,Francesca Langone,Irene Garzia,Maria De Lucia, Imma Fichera,Rosa Vitale,Veronica Bignone,Fabio Giovanni Tucci,Federica Mori,Adriano Leuzzi,
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Nathalie Demotte,Grégoire Wieërs,Patrick Van Der Smissen,Muriel Moser,Christopher Schmidt,Kris Thielemans, Jean-Luc Squifflet,Birgit Weynand,Javier Carrasco, Christophe Lurquin,Pierre J. Courtoy,Pierre van der Bruggen
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JOURNAL OF CLINICAL MEDICINEno. 13 (2021): 2872
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