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Balaram's main area of research has been the investigation of the structure, conformation, and biological activity of designed and natural peptides. To do this, he has extensively used techniques such as Nuclear Magnetic Resonance spectroscopy, Infrared spectroscopy, and Circular Dichroism, along with X-ray crystallography. He has been a major contributor to the evaluation of factors influencing the folding and conformations of designed peptides, and has investigated structural elements playing a key role in the formation of secondary structural motifs such as helices, beta turns, and sheets. Along with Isabella Karle, a frequent collaborator, he has also pioneered the use of alpha-amino isobutyric acid to induce and retain helicity and constrain peptide conformations.
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Madhumati S Vaishnav,Namita Kumari, Sathyanarayana Srikanta,Vinaya Simha,Patnam R Krishnaswamy,Padmanabhan Balaram,Navakanta Bhat
Metabolic syndrome and related disorders (2024)
CURRENT SCIENCEno. 12 (2021): 1820-1826
CURRENT SCIENCEno. 11 (2021): 1663-1666
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