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I am interested in understanding the interplay between (un)natural compounds and secondary active transporters involved in health and disease. My primary focus is on human intestinal transporters, which play important roles in nutrient and drug absorption. Furthermore, in cancers, expression of several of these transporters is upregulated due to high metabolic activity. Thus, molecular understanding of the structure and mechanism of these transporters may hold important clues towards improving both drug absorption and cancer therapy. Our experimental portfolio includes X-ray crystallography, functional assays, site-directed mutagenesis, biophysical analyses and bioinformatics.
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论文共 95 篇作者统计合作学者相似作者
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Agnese Chiara Pippione,Sandra Kovachka, Chiara Vigato, Laura Bertarini, Iole Mannella,Stefano Sainas,Barbara Rolando, Enrica Denasio, Helen Piercy-Mycock, Linda Romalho, Edoardo Salladini,Salvatore Adinolfi,
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2024): 116193-116193
Hani Gharabli,Maria Rafiq, Anna Iqbal, Ruyu Yan,Nanda G Aduri,Neha Sharma,Bala K Prabhala,Osman Mirza
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FEMS microbiology letters (2023)
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Frontiers in plant science (2023): 1219783
Journal of Biomolecular Structure & Dynamicspp.1-10, (2023)
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Biochemical and biophysical research communications (2023): 42-49
Molecular and Cellular Biochemistrypp.1-12, (2023)
biorxiv(2023)
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