Orhan Aktas

基本信息

Career Trajectory

Bio

Research Interest
Overall interest: Clinical and experimental neuroimmunology Clinical focus:

Multiple Sclerosis and related inflammatory diseases of the CNS
Neuromyelitis optica (NMO or Devic’s syndrome) and NMO-spectrum disorders
Development of novel clinical markers for neurodegeneration such as optical coherence tomography (OCT)
Transfer of novel therapy strategies into clinical studies (investigator-initiated trials, IITs)
Experimental focus:

Mechanisms of inflammatory degeneration and disturbed regeneration in the CNS
Epigenetic regulation of neural progenitor cell (NPC) homeostasis, with focus on redox-dependent histone deacetylases (sirtuins)
Experimental autoimmune encephalomyelitis (EAE)

Research Interests

Papers共 491 篇Author StatisticsCo-AuthorSimilar Experts

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Comorbidities Are Associated with Unfavorable Outcome in Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorders and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: Exploratory Study from the CROCTINO Cohort

Sara Samadzadeh,Frederike Cosima Oertel, Hadi Salih,Ting-Yi Lin, Seyedamirhosein Motamedi,Claudia Chien,Lawrence J Cook,Marco Aurélio Lana-Peixoto, Mariana Andrade Fontenelle,Ho Jin Kim,Jae-Won Hyun, Su-Kyung Jung, Jaqueline Palace,Adriana Roca-Fernandez,Maria Isabel Leite,Srilakshmi M Sharma,Fereshteh Ashtari,Rahele Kafieh,Alireza Dehghani,Mohsen Pourazizi,Lekha Pandit,Anitha Dcunha,Orhan Aktas,Marius Ringelstein,Philipp Albrecht, Eugene F May,Caryl Tongco,Letizia Leocani,Marco Pisa,Marta Radaelli,Bernardo Sánchez-Dalmau,Elena H Martinez-Lapiscina,Hadas Stiebel-Kalish,Mark A Hellmann,Itay Lotan,Sasitorn Siritho,Jérôme de Seze, Thomas Senger,Joachim Havla,Romain Marignier,Caroline Froment Tilikete,Alvaro Cobo-Calvo, Denis Bichuetti,Ivan Maynart Tavares,Kerstin Soelberg,Ayse Altintas,Rengin Yildirim, Uygur Tanriverdi,Anu Jacob, Saif Huda, Zoe Rimler,Allyson Reid, Yang Mao-Draayer,Pablo Villoslada, Ibis Soto de Castillo,Ari Green,Axel Petzold, Michael R Yeaman, Terry J Smith,Alexander U Brandt, Hanna G Zimmermann,Friedemann Paul,Nasrin Asgari, Guthy Jackson Charitable Foundation – International Clinical Consortium and CROCTINO Collaborators

European journal of neurologyno. 6 (2025): e70214-e70214

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Rituximab As First-Line Compared to Escalation Immunotherapy is Associated with Lower Disability Accumulation in Aquaporin-4-IgG-Positive Neuromyelitis Optica Spectrum Disorder: A Multicenter Cohort Study from Germany and the United Kingdom

Daniel Engels,Chiara Rocchi, Mirasol Forcadela,Pakeeran Siriratnam,Marius Ringelstein, Martin W Hümmert, Katrin Giglhuber,Achim Berthele,Corinna Trebst,Orhan Aktas,Joachim Havla, Saif Huda,Tania Kümpfel

European journal of neurologyno. 6 (2025): e70243-e70243

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RENEWED: A Follow-Up Study of the Opicinumab Phase 2 RENEW Study in Participants with Acute Optic Neuritis

Orhan Aktas,Focke Ziemssen,Tjalf Ziemssen,Alexander Klistorner,Helmut Butzkueven,Guillermo Izquierdo,Letizia Leocani,Laura J. Balcer,Steven L. Galetta,Carmen Castrillo-Viguera, Daniel P. Bradley,Maria L. Naylor,Shibeshih Belachew,Nathalie Franchimont,Bing Zhu,Wenting Cheng, RENEWED Investigators

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2025)

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Worse Recovery from Acute Attacks and Faster Disability Accumulation Highlights the Unmet Need for Improved Treatment in Patients with Late-Onset Neuromyelitis Optica Spectrum Disorders (COPTER-LO Study)

Julian Reza Kretschmer,Daria Tkachenko,Tania Kümpfel,Joachim Havla, Daniel Engels,Friedemann Paul,Patrick Schindler,Judith Bellmann-Strobl,Achim Berthele, Katrin Giglhuber, Clarissa Zappe,Luisa Klotz, Lisa Revie, Eva Dawin,Makbule Senel,Hayrettin Tumani,Florian Then Bergh,Clemens Warnke,Markus Kraemer,Annette Walter,Antonios Bayas,Uwe K Zettl, Ann-Sophie Lauenstein,Yavor Yalachkov,Thorleif Etgen,Matthias Kaste,Felix Luessi,Stefan Gingele, Sarah Passoke,Martin S Weber, Jörn Peter Sieb,Axel Haarmann,Patrick Oschmann, Veit Rothhammer,Christian Geis,Markus C Kowarik, Peter Kern,Matthias Grothe, Heike Stephanik,Klemens Angstwurm,Frank Hoffmann, Ulrike Wallwitz,Brigitte Wildemann,Sven Jarius,Jan-Patrick Stellmann, Thivya Pakeerathan, Carolin Schwake,Ilya Ayzenberg,Ingo Kleiter, Katinka Fischer,Orhan Aktas,Marius Ringelstein, Vivien Häußler,Corinna Trebst, Martin W Hümmert

Frontiers in immunology (2025): 1575613-1575613

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Intravenous Immunoglobulin As First-Line Acute Treatment in Adults with Autoimmune Encephalitis Caused by Antibodies to NMDAR, LGI1 and CASPR2

Joyce Christin Rittel, Dominica Hudasch,Kathrin Doppler,Florian Then Bergh, Martin Lesser,Orhan Aktas, Michael Nagel,Hagen B. Huttner,Kevin Rostasy, Simone Tauber,Manuel A. Friese,Michael Malter,Marie Madlener,Andrea Kraft,Frank Hoffmann,Jan Lewerenz,Makbule Senel,Jonathan Wickel,Christian Geis,Andreas Moser,Klaus-Peter Wandinger,Thorsten Bartsch,Frank Leypoldt,Franziska Thaler,Tania Kümpfel,Sven Meuth,Nico Melzer,Carsten Finke,Harald Prüss,Martin Stangel,Kurt-Wolfram Sühs

Journal of Neurologyno. 4 (2025): 1-14

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Rapid Differentiation of MOGAD and MS after a Single Optic Neuritis

T. Pakeerathan,J. Havla,C. Schwake,A. Salmen,M. Ringelstein,O. Aktas,M. Weise, J. A. Gernert,B. Kornek,G. Bsteh,A.-K. Pröbstel,A. Papadopoulou,L. Kulsvehagen, A. B. Ayroza Galvão Ribeiro Gomes,N. Cerdá-Fuertes,F. C. Oertel, A. S. Duchow,F. Paul,J. P. Stellmann, N. Stolowy,K. Hellwig,C. Schneider-Gold,T. Kümpfel,R. Gold,P. Albrecht,I. Ayzenberg

JOURNAL OF NEUROLOGY（2024）

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Serum Glial Fibrillary Acidic Protein (sgfap) As Potential Biomarker for Cognition and Neuropsychiatric Symptoms in Multiple Sclerosis

Tristan Koelsche,Alina Renner,Orhan Aktas,Sharon Baetge,Melanie Filser,Philipp Albrecht,Falk Steffen,Stefan Bittner,Sven Meuth,Marc Pawlitzki,Iris-Katharina Penner

MULTIPLE SCLEROSIS JOURNALno. 3 (2024): 970-971

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Eculizumab Use in Neuromyelitis Optica Spectrum Disorders: Routine Clinical Care Data from a European Cohort

MULTIPLE SCLEROSIS JOURNAL（2024）

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Papers共 491 篇Author StatisticsCo-AuthorSimilar Experts