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T cells are important white blood cells that continually circulate in the body in search of the molecular signatures ('antigens') of infection and cancer. When encountering such antigens T cells become activated and subsequently initiate immune responses in order to clear these threats. Their inappropriate activation towards innocuous and endogenous antigens leads to allergic and autoimmune responses, respectively. A key aim of the laboratory is to understand the 'calculation' that T cells make in deciding to respond to abnormal cells whilst ignoring healthy cells.
The calculation that T cells make is performed by their complex signalling machinery that integrates signals from the T cell receptor with a host of other, accessory, receptors on their surface. We are using a combination of quantitative experiments and mathematical modelling to uncover the biochemical mechanisms used by T cells to integrate these signals.
The calculation that T cells make is performed by their complex signalling machinery that integrates signals from the T cell receptor with a host of other, accessory, receptors on their surface. We are using a combination of quantitative experiments and mathematical modelling to uncover the biochemical mechanisms used by T cells to integrate these signals.
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论文共 104 篇作者统计合作学者相似作者
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Linnea Z. Drexhage,Shengpan Zhang,Maeva Dupont,Franziska Ragaller, Ellen Sjule, Jose Cabezas-Caballero,Lachlan P. Deimel, Helen Robertson,Rebecca A. Russell,Omer Dushek,Erdinc Sezgin, Niloofar Karaji,
Nature Communicationsno. 1 (2024): 1-13
Ian B. Robertson, Rachel Mulvaney,Nele Dieckmann, Alessio Vantellini, Martina Canestraro,Francesca Amicarella, Ronan O'Dwyer,David K. Cole,Stephen Harper,Omer Dushek,Peter Kirk
CLINICAL AND EXPERIMENTAL IMMUNOLOGYno. 2 (2024): 105-119
Ashna Patel, Violaine Andre, Sofia Bustamante Eguiguren,Michael I Barton, Jake Burton,Eleanor M Denham,Johannes Pettmann, Alexander M Mørch,Mikhail A Kutuzov,Jesús A Siller-Farfán,Michael L Dustin, P Anton van der Merwe,
The EMBO Journalno. 1 (2024): 132-150
Ashna Patel, V André, Sofía Bustamante Eguiguren,Michael I Barton,Eleanor M Denham,Johannes Pettmann, Alexander M. Mørch,Mikhail A. Kutuzov,Jesús A. Siller-Farfán,Michael L. Dustin, P. Anton van der Merwe,Omer Dushek
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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biorxiv(2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Ashna Patel, Violaine Andre, Sofia Bustamante Eguiguren,Michael I. Barton,Eleanor M. Denham,Johannes Pettmann, Alexander M Mørch,Mikhail A. Kutuzov,Jesús A. Siller-Farfán,Michael L. Dustin, P. Anton van der Merwe,Omer Dushek
biorxiv(2023)
Timo Peters,Vanessa Muehlgrabner,Rubi M.H. Velasco Cardenas,Rene Platzer,Janett Gohring,Benjamin Salzer, Angelika Plach, Maria Hoehrhan,Iago Doel-Perez, Vasco Dos Reis Goncalves, Jesus Siller Farfan,Manfred Lehner,
biorxiv(2023)
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