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Neural stem cells (NSCs) possess the capability for self-renewal and are multipotent, that is, they can give rise to both neurons and glial cells. Embryonic NSCs are expected as a source for transplantation therapy, and adult NSCs as a basis of noninvasive treatment of neurological disorders. However, because the fate of embryonic NSCs is generally predetermined and restricted temporally, a given embryonic NSC cannot generate all of the cell types existing in the CNS. For example, early NSCs generate neurons but not glia; later NSCs generate both types of cells, however, they cannot give rise to early-born neurons. Meanwhile, actual use of adult NSCs for regenerative medicine is a vision far from being fulfilled because of the as-yet unexplored physiology and mechanisms of adult neurogenesis.To resolve these problems, we propose to establish in-vitro culture systems, and to develop a powerful model for investigating the mechanisms underlying early CNS development. Furthermore, we are examining adult neurogenesis both anatomically and physiologically by combining comprehensive in-vitro analyses, such as DNA microarray and ChIP-sequencing, and in-vivo analyses using knockout or knock-in mice. Findings from these approaches are expected to be applicable to regenerative therapy for neurodegenerative disorders.
Research Areas【 Display / hide 】
Life Science / Molecular biology (Molecular Biology)
Life Science / Developmental biology (Developmental Biology)
Life Science / Neuroscience-general (General Neuroscience)
Research Areas【 Display / hide 】
Life Science / Molecular biology (Molecular Biology)
Life Science / Developmental biology (Developmental Biology)
Life Science / Neuroscience-general (General Neuroscience)
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论文共 1809 篇作者统计合作学者相似作者
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Spine surgery and related researchno. 1 (2024): 22-28
Neural regeneration researchno. 4 (2024): 818-824
Neuroscience Research (2024)
PLOS ONEno. 2 (2024): e0297273-e0297273
crossref(2024)
Sopak Supakul,Rei Murakami, Chisato Oyama,Tomoko Shindo,Yuki Hatakeyama, Maika Itsuno,Hiroko Bannai,Shinsuke Shibata,Sumihiro Maeda,Hideyuki Okano
crossref(2024)
Kinya Matsuo, Kazuhiro Nagata, Ryusei Umeda, Takaya Shiota,Satoru Morimoto,Naoki Suzuki,Masashi Aoki,Hideyuki Okano, Masayuki Nakamori,Hideaki Nishihara
biorxiv(2024)
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