基本信息
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Research Interests
The central topic of the research in the Wiest group is how molecules interact and react. The structure and energetics of non-covalent complexes and transition states is probed theoretically and experimentally. The detailed understanding of intermolecular interactions can then be exploited for the design of assays for biophysical studies and for drug design. Four distinct areas of research are currently under investigation: (1) development of epigenetic modulators targeting histone deacetylases and bromodomains as chemical tools and drug leads, (2) rare and neglected diseases, specifically Niemann Pick Type C disease, (3) mechanistic studies of transition metal and enzyme catalyzed reactions, and (4) development of Q2MM methods for the virtual screening of chiral ligands for asymmetric catalysis.
The research in the Wiest group uses a wide range of experimental and computational methods that are applied to fundamental and applied problems in organic and biophysical chemistry. In this work, we collaborate with a number of other researchers in synthetic chemistry, biology, physics, and at medical schools at Notre Dame and around the world.
研究兴趣
论文共 347 篇作者统计合作学者相似作者
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Yogesh Narkhede, Roopashi Saxena,Tej Sharma, Jacob P Conarty, Valentina Toro Ramirez,Balindile B Motsa,Souad Amiar,Sheng Li,Prem P Chapagain,Olaf Wiest,Robert V Stahelin
Angus Keto,Taicheng Guo, Morgan Underdue,Thijs Stuyver,Connor Coley,Xiangliang Zhang,Elizabeth Krenske,Olaf Wiest
crossref(2024)
Taicheng Guo,Xiuying Chen, Yaqi Wang, Ruidi Chang,Shichao Pei,Nitesh V. Chawla,Olaf Wiest,Xiangliang Zhang
CoRR (2024)
引用0浏览0EI引用
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arxiv(2023)
引用33浏览0EI引用
33
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Taicheng Guo,Kehan Guo,Bozhao nan, Zhengwen Liang,Zhichun Guo,Nitesh V. Chawla,Olaf Wiest,Xiangliang Zhang
CoRR (2023)
引用12浏览0EI引用
12
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Science immunologyno. 81 (2023): eade4656-eade4656
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