基本信息
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职业迁徙
个人简介
I pioneered, with Yoshio Maruyama, patch clamp single channel and whole-cell current recordings in epithelial cells. We discovered hormone-evoked, messenger-mediated ion channel activation (Maruyama & Petersen Nature 1982a,b), voltage-activation of epithelial ion channels (Maruyama et al Nature 1983a,b) and integrated these data into the first model of how ion channels control exocrine fluid secretion (Petersen & Maruyama Nature 1984 [ISI [WoS] Citation Classic]; Petersen J Physiol 1992). I discovered sub-cellular Ca2+ spiking in epithelial cells (Wakui et al Nature 1989, Cell 1990; Thorn et al Cell 1993), messenger-mediated Ca2+ release from the nuclear envelope (Gerasimenko et al Cell 1995) as well as the secretory granules (Gerasimenko et al Cell 1996) and intracellular Ca2+ tunnels (Mogami et al Cell 1997). Together with Oleg and Julia Gerasimenko, we demonstrated the crucial role of Ca2+ release channels and store-operated Ca2+ entry in Acute Pancreatitis (Raraty et al PNAS 2000; Gerasimenko et al PNAS 2009; 2011), provided proof-of-principle for Ca2+ release-activated Ca2+ (CRAC) channel blockade as a treatment of severe Acute Pancreatitis (Gerasimenko et al PNAS 2013; J Physiol 2014) and discovered a critical role for pancreatic stellate cells in this disease (Ferdek et al J Physiol 2016; Gryshchenko et al J Physiol 2016,2018). More recently, we have discovered Ca2+ signalling events in pancreatic immune cells that are likely to be important for initiating the cytokine storm that is responsible for severe, and often fatal, cases of Acute Pancreatitis (Gryshchenko et al Function 2021).
研究兴趣
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Functionno. 1 (2023): zqae001-zqae001
Function (Oxford, England)no. 6 (2023)
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Function (Oxford, England)no. 4 (2023): zqad032-zqad032
FUNCTIONno. 5 (2022): zqac045-zqac045
FUNCTIONno. 1 (2022)
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