基本信息
浏览量:411
职业迁徙
个人简介
Prof. Nobutaka Hattori is a Chairman and Professor of the Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
He was involved in research about molecular mechanisms of Parkinson’s disease (PD) since 1989. He found decrease in the amount of complex I in the substantia nigra of PD patients. More recently, his collaborators and he identified the disease gene for an autosomal recessive form of young onset familial PD, and named the gene as “parkin”. This is the second form of familial PD in which the disease gene was identified. In addition, they found that the gene product, parkin was direct linked to ubiquitin- proteasome pathway as an ubiquitin ligase. This discovery suggested that protein degradation system was involved in the pathogenesis of not only monogenic form of PD but also sporadic PD. He has more than 300 peer-reviewed papers. Now he has been working hard for investigating and developing therapeutic methods not only for PD but other neurological diseases.
He was involved in research about molecular mechanisms of Parkinson’s disease (PD) since 1989. He found decrease in the amount of complex I in the substantia nigra of PD patients. More recently, his collaborators and he identified the disease gene for an autosomal recessive form of young onset familial PD, and named the gene as “parkin”. This is the second form of familial PD in which the disease gene was identified. In addition, they found that the gene product, parkin was direct linked to ubiquitin- proteasome pathway as an ubiquitin ligase. This discovery suggested that protein degradation system was involved in the pathogenesis of not only monogenic form of PD but also sporadic PD. He has more than 300 peer-reviewed papers. Now he has been working hard for investigating and developing therapeutic methods not only for PD but other neurological diseases.
研究兴趣
论文共 1341 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
JOURNAL OF NEURAL TRANSMISSION (2024)
Yusei Miyazaki,Shigehisa Ura,Kazuhiro Horiuchi, Takeshi Matsuoka,Hideki Houzen,Kazufumi Tsuzaka, Yuichi Makino, Manami Koshida,Genko Oyama, Chika Sato,Ryoji Naganuma,Itaru Amino,
Clinical and Experimental Neuroimmunology (2024)
Journal of Neural Transmissionpp.1-3, (2024)
Shohei Fujita,Borjan Gagoski,Ken-Pin Hwang,Akifumi Hagiwara,Marcel Warntjes,Issei Fukunaga,Wataru Uchida,Yuya Saito, Towa Sekine, Rina Tachibana, Tomoya Muroi, Toshiya Akatsu,
Movement disorders clinical practiceno. 4 (2024): 352-362
Stem Cell Research (2024): 103270-103270
Ines Debove,Steffen Paschen,Deborah Amstutz, Francisco Cardoso,Jean-Christophe Corvol,Victor S. C. Fung,Anthony E. Lang,Pablo Martinez Martin,Maria C. Rodriguez-Oroz,Daniel Weintraub,Paul Krack, Guenther Deuschl,
Movement disorders : official journal of the Movement Disorder Societyno. 2 (2024): 235-248
JOURNAL OF NEUROSCIENCE RESEARCHno. 3 (2024): e25302-e25302
Neural regeneration researchno. 6 (2024): 1197-1198
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn