A practicing physician-scientist with a focus in melanoma her translational and basic science laboratory researches immune barrier homeostasis and the influence on tumor immune surveillance in both mice and humans. The Anandasabapathy lab seeks to understand how tissue immune homeostasis is conditioned, maintained, and co-opted by tumors, leading to tumor immune escape. Her group studies DC: T cell cross-talk in barrier sites, and in tumors (including melanoma). They also study the role of DC in protein vaccine immunity, smallpox immunization, and TRM regulation, and seek to understand how the hierarchy of DC programs in tissues contributes to their behavior.