His main areas of interests are mobile and computer security, machine learning, and data mining. In addition to his contributions to the cyber security domain, Dr. Nissim is also interested in the biomedical informatics domain, in which he has published a number of papers regarding the efficient classification of condition severity. He is also a lecturer on cyber security and machine learning topics, both in the Information Systems Engineering Department at BGU, as well as in the Industrial Engineering and Management Department at Tel Aviv University.