Nikolay V. Dokholyan (Nikolay Dokholyan)
教授
Penn State Neuroscience Institute;Penn State Cancer Institute;Department of Pharmacology
Penn State College of Medicine;Penn State Clinical and Translational Science Institute;Department of Biochemistry & Molecular Biology, Penn State College of Medicine
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个人简介
The mission of Dr. Nikolay Dokholyan's laboratory is to develop and apply integrated computational and experimental strategies to understand, sense and control misfolded proteins in order to uncover the etiologies of human neurodegenerative diseases and develop therapeutics to fight them.
The lab aims to understand the molecular disease mechanisms of ALS: How does the misfolding of superoxide dismutase (SOD1) lead to the formation of toxic oligomeric intermediates? Using biochemical and biophysical approaches and innovative computation, the Dokholyan lab determined putative structures of SOD1 oligomers and is currently elucidating the downstream pathways that lead to motorneuron death. Structures of toxic oligomers provide targets for drug discovery, which the lab is pursuing.
研究兴趣
论文共 291 篇作者统计合作学者相似作者
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crossref(2024)
BRIEFINGS IN BIOINFORMATICSno. 1 (2024)
Hemerson Casado Gama,Mariana A. Amorós,Mykaella Andrade de Araújo,Congzhou M. Sha, Mirella P. S. Vieira, Rayssa G.D. Torres, Gabriela F. Souza, Janaína A.Junkes,Nikolay V. Dokholyan,Daniel Leite Góes Gitaí,Marcelo Duzzioni
Non-coding RNA Researchno. 2 (2024): 523-535
bioRxiv : the preprint server for biology (2024)
Structural dynamics (Melville, N.Y.)no. 4 (2023): 044301
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Negar Khazan,Emily R Quarato,Niloy A Singh,Cameron W A Snyder,Taylor Moore, John P Miller,Masato Yasui,Yuki Teramoto,Takuro Goto,Sabeeha Reshi, Jennifer Hong, Naixin Zhang,
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Shivani Sujay Godbole,Nikolay Dokholyan
bioRxiv : the preprint server for biology (2023)
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