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The Joshi laboratory uses intricate tumor models and advanced approaches to investigate immune cell interactions with developing tumors. The goal is to determine mechanistically why these interactions do not lead to more potent anti-tumor responses and to identify entry points for modulating these interactions through genetic manipulation and therapeutic intervention. Our studies focus on using established complex mouse models to investigate how subtypes of T cells function in the tumor microenvironment and how their interactions with other immune cell types impacts tumor development. Our laboratory combines advanced genetic modeling of mice and immunologic techniques to address fundamental questions in tumor immunology.
The Joshi laboratory uses intricate tumor models and advanced approaches to investigate immune cell interactions with developing tumors. The goal is to determine mechanistically why these interactions do not lead to more potent anti-tumor responses and to identify entry points for modulating these interactions through genetic manipulation and therapeutic intervention. Our studies focus on using established complex mouse models to investigate how subtypes of T cells function in the tumor microenvironment and how their interactions with other immune cell types impacts tumor development. Our laboratory combines advanced genetic modeling of mice and immunologic techniques to address fundamental questions in tumor immunology.
研究兴趣
论文共 96 篇作者统计合作学者相似作者
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Madison S Strine,Eric Fagerberg,Patrick W Darcy, Gabriel M Barrón,Renata B Filler,Mia Madel Alfajaro, Nicole D'Angelo-Gavrish, Fang Wang,Vincent R Graziano,Bridget L Menasché,Martina Damo,Ya-Ting Wang,
Melanie A. Reuter, Madelynn Tucker, Zara Marfori, Rahaf Shishani,Jessica Miranda Bustamante, Rosalinda Moreno,Michael L. Goodson,Allison Ehrlich,Ameer Y. Taha,Pamela J. Lein,Nikhil Joshi,Ilana Brito,
GUT MICROBESno. 1 (2024): 2315632-2315632
Julie F. Cheung, Shudipto Wahed, Elaine Cheng,Kelli Connolly, Brian G. Hunt, Srividhya Venkatesan, Jennifer Loza, Ishan Bansal, Emily Borr, Wei Wei,Ivana William,Brittany Fitzgerald,
crossref(2024)
Magdalena M. Coman,Lajos Pusztai,Regina Hooley, Liva Andreveja,Leah Kim,Nikhil Joshi,Alexey Bersenev,Diane Krause,Tristen S. Park
JOURNAL OF IMMUNOTHERAPYno. 2 (2024): 49-53
CANCER RESEARCHno. 2 (2024)
Goran Micevic,Andrew Daniels,Karine Flem-Karlsen, Koonam Park, Ronan Talty,Meaghan McGeary,Haris Mirza,Holly N Blackburn,Esen Sefik,Julie F Cheung,Noah I Hornick,Lilach Aizenbud,
Proceedings of the National Academy of Sciences of the United States of Americano. 30 (2023)
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Journal of Vascular and Interventional Radiologyno. 3 (2023): 395-403.e5
Jacqueline E Mann,Liliana Lucca,Matthew R Austin, Ross D Merkin,Marie E Robert, Badr Al Bawardy,Khadir Raddassi,Lilach Aizenbud,Nikhil S Joshi,David A Hafler,Clara Abraham,Kevan C Herold,
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Journal of Immunologyno. 1 (2023): 236.01-236.01
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