Nigel Kee

I am a stem cell and developmental biologist with an interest in translating stem cell technologies into clinical applications. I use RNA-sequencing, particularly at the single-cell level, to interrogate the development of clinically relevant cell-types. My work focuses on improving differentiation protocols for dopaminergic and motor neuron lineages of the CNS, that degenerate in PD or ALS. Such efforts improve the efficacy of cell transplantation strategies to treat PD, and in vitro models employing ALS patient derived hiPSCs to screen potential therapeutics. These fields have historically lacked the high-granularity, high-throughput data of single-cell RNA-seq. Together with other emerging technologies, they may genuinely deliver on the clinical potential of the stem cell field.