Nigel J Pyne (Nigel Pyne)

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Lysolipid (sphingosine 1-phosphate, lysophoshatidic acid) receptor signalling in health and disease with specific focus on cancer and cardiovascular/inflammatory disease Cross talk regulation between lysolipid receptors and growth factor receptors/oncogenes (e.g. PDGFR, HER2, EGFR and TRK A) Translational biology of lysolipids (e.g. drug discovery and biomarker identification) Cyclic AMP/cyclic GMP signalling

Research Interests

Papers共 257 篇Author StatisticsCo-AuthorSimilar Experts

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ATAD1 Gene Rescue of Zellweger Spectrum Disorders Via Targeting of Shared Common Mechanism

J. Bonkowsky,T. J. Stevenson, P. Chang, D. Baronio,E. Nuebel,A. Bradbury,N. Pyne

ANNALS OF NEUROLOGY (2025): S102-S103

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Sphingosine 1-Phosphate Turnover in GtoPdb V.2023.1

Nigel J Pyne,Susan Pyne

IUPHAR/BPS Guide to Pharmacology CITEno. 1 (2023)

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Dependence of IL-7R-Mediated Signaling on Sphingosine Kinase Activity in Acute Lymphoblastic Leukemia, but Not Healthy Lymphoid Cells, is an Exploitable Therapeutic Vulnerability

Marta B. Fernandes,Alice Melao, Tatiana Araujo,Ana Cachucho,David R. Adams,Jeongah Oh,Afonso R. M. Almeida,Federico Torta,Vasco Barreto,Susan Pyne,Timothy Hla,Nigel J. Pyne,Joao T. Barata

BLOOD (2023)

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Interleukin-7 Receptor Α Mutational Activation Can Initiate Precursor B-cell Acute Lymphoblastic Leukemia

Afonso R. M. Almeida,João L. Neto,Ana Cachucho, Mayara Euzébio,Xiangyu Meng,Rathana Kim,Marta B. Fernandes, Beatriz Raposo,Mariana L. Oliveira,Daniel Ribeiro,Rita Fragoso,Priscila P. Zenatti, Tiago Soares,Mafalda R. de Matos,Juliana Ronchi Corrêa,Mafalda Duque,Kathryn G. Roberts,Zhaohui Gu,Chunxu Qu, Clara Pereira,Susan Pyne,Nigel J. Pyne,Vasco M. Barreto,Isabelle Bernard-Pierrot, Emannuelle Clappier,Charles G. Mullighan,Ana R. Grosso,J. Andrés Yunes,João T. Barata

Nature Communications（2021）

Cited33Views0WOSNATUREBibtex

Dihydroceramide Desaturase Functions As an Inducer and Rectifier of Apoptosis: Effect of Retinol Derivatives, Antioxidants and Phenolic Compounds

Alsanafi Mariam,Brown Ryan D. R.,Oh Jeongah,Adams David R.,Torta Federico,Pyne Nigel J.,Pyne Susan

Cell Biochemistry and Biophysics（2021）

Cited7Views0WOSBibtex

A New Model for Regulation of Sphingosine Kinase 1 Translocation to the Plasma Membrane in Breast Cancer Cells

Ryan D. R. Brown,Ben E. P. Veerman,Jeongah Oh,Rothwelle J. Tate,Federico Torta,Margaret R. Cunningham,David R. Adams,Susan Pyne,Nigel J. Pyne

Journal of Biological Chemistry（2021）

Cited2Views0WOSBibtex

Validation of Highly Selective Sphingosine Kinase 2 Inhibitors SLM6031434 and HWG-35D As Effective Anti-Fibrotic Treatment Options in a Mouse Model of Tubulointerstitial Fibrosis

Stephanie Schwalm,Sandra Beyer,Redona Hafizi,Sandra Trautmann,Gerd Geisslinger,David R. Adams,Susan Pyne,Nigel Pyne,Liliana Schaefer,Andrea Huwiler,Josef Pfeilschifter

Cellular Signalling（2020）

Cited12Views0WOSBibtex

Recent Advances in the Role of Sphingosine 1‐phosphate in Cancer

Nigel J. Pyne,Susan Pyne

FEBS lettersno. 22 (2020): 3583-3601

Cited0Views0Bibtex

The Regulation of P53, P38 MAPK, JNK and XBP-1s by Sphingosine Kinases in Human Embryonic Kidney Cells

Mariam Alsanafi,Samuel L. Kelly,Melissa McNaughton,Alfred H. Merrill,Nigel J. Pyne,Susan Pyne

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids（2020）

Cited2Views0WOSBibtex

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Papers共 257 篇Author StatisticsCo-AuthorSimilar Experts