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An imbalance in neuronal and synaptic excitability is a common abnormality observed in patients with various psychiatric and neurological disorders, including autism spectrum disorders, epilepsy and Alzheimer's disease. The dysregulation of excitability is thought to exacerbate disease symptoms. Identifying and understanding the mechanisms underlying the dysregulation of excitability could reveal novel therapeutic targets for these diseases. To achieve this goal, we utilize various approaches including molecular and cell biology, biochemistry, electrophysiology, and mouse genetics to understand the regulation of excitability homeostasis at synaptic, neuronal, network and system levels, and how the deficits of those affect behavior in diseases.
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论文共 62 篇作者统计合作学者相似作者
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Vipendra Kumar,Kwan Young Lee, Anirudh Acharya, Matthew S Babik,Catherine A Christian-Hinman,Justin S Rhodes,Nien-Pei Tsai
EMBO molecular medicineno. 3 (2024): 506-522
Arojit Mitra, Sean P Deats,Price E Dickson,Jiuhe Zhu,Justin Gardin, Brian J Nieman,R Mark Henkelman,Nien-Pei Tsai,Elissa J Chesler,Zhong-Wei Zhang,Vivek Kumar
EMBO Reportsno. 3 (2024): 1233-1255
JOURNAL OF NEUROCHEMISTRYno. 1 (2023): E2-E2
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Molecular psychiatryno. 9 (2023): 3782-3794
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Brian C. Baculis, Harish Kesavan, Amanda C. Weiss,Edward H. Kim, Gregory C. Tracy,Wenhao Ouyang,Nien-Pei Tsai,Hee Jung Chung
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