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职业迁徙
个人简介
I am currently working as a Clinical Research Fellow in the MRC Molecular Haematology Unit supervised by Prof Paresh Vyas and Prof Doug Higgs.
My research focuses on how mutations affecting epigenetic regulators lead to clonal expansion in haematopoietic stem and progenitor cells. Proteins that control DNA methylation, such as DNMT3A and TET2, are important in stem cell differentiation and regulating how genes are expressed. Mutations in these genes are commonly found in blood cells of healthy older people, lead to clonal expansion, and are associated with increased risk of developing acute myeloid leukaemia (AML) and other haematological cancers. Through this work, we hope to gain a better understanding of how AML develops and identify new therapeutic targets to improve treatment for patients with leukaemia.
My research focuses on how mutations affecting epigenetic regulators lead to clonal expansion in haematopoietic stem and progenitor cells. Proteins that control DNA methylation, such as DNMT3A and TET2, are important in stem cell differentiation and regulating how genes are expressed. Mutations in these genes are commonly found in blood cells of healthy older people, lead to clonal expansion, and are associated with increased risk of developing acute myeloid leukaemia (AML) and other haematological cancers. Through this work, we hope to gain a better understanding of how AML develops and identify new therapeutic targets to improve treatment for patients with leukaemia.
研究兴趣
论文共 20 篇作者统计合作学者相似作者
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Cell Stem Cellno. 5 (2023): 722-740.e11
BLOODno. 20 (2023): 1697-1707
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Blood cancer discoveryno. 4 (2023): 276-293
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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STAR PROTOCOLSno. 4 (2023)
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Sylvie D Freeman,Abin Thomas,Ian Thomas,Paresh Vyas,Amanda Gilkes,Marlen Metzner,Niels Asger Jakobsen,Alison Kennedy, Amy Moore, Nuria Marquez Almuina,Sarah Burns,Sophie King,
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