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We have a long-standing interest in 3D culture techniques for head and neck cancer (HNC) and in the establishment of preclinical oncological models to study immune cell/ TME/ tumor interactions in response to treatment.
Immuno-oncological questions are addressed by the employment of
(i) established heterotypic spheroids from patient-derived cancer and stromal cells,
(ii) ex vivo tissue cultures preserving the structural architecture and the TME using patient-derived explants,
(iii) and 3D scaffold-based organotypic co-culture models.
Current projects on HNC models focus on the role of signaling cascades in response to anti-PD-1/PD-L1 immunotherapy and the generation of ex vivo/ immune cell co-cultures. 3D models are characterized in more detail using live-cell imaging. Bioprinting enables rapid high-throughput generation of spatially consistent spheroids.
Immuno-oncological questions are addressed by the employment of
(i) established heterotypic spheroids from patient-derived cancer and stromal cells,
(ii) ex vivo tissue cultures preserving the structural architecture and the TME using patient-derived explants,
(iii) and 3D scaffold-based organotypic co-culture models.
Current projects on HNC models focus on the role of signaling cascades in response to anti-PD-1/PD-L1 immunotherapy and the generation of ex vivo/ immune cell co-cultures. 3D models are characterized in more detail using live-cell imaging. Bioprinting enables rapid high-throughput generation of spatially consistent spheroids.
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95th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e. V., Bonn Laryngo-Rhino-Otologie (2024)
CELLSno. 2 (2024): 141
Claudia Scherl, Marie Otto,Ibrahim Ghanem, Javier Oviglia, Fabian Sadi, Tirza Gnilka,Nicole Rotter,Lena Zaubitzer,Jan Stallkamp
HNOno. 2 (2024): 76-82
95th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e. V., Bonn Laryngo-Rhino-Otologie (2024)
95. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V., Bonn Laryngo-Rhino-Otologie (2024)
Luisa Tengler, Julia Schütz, Moritz Tiedtke,Jadwiga Jablonska,Marie-Nicole Theodoraki, Katja Nitschke,Christel Weiß,Elena Seiz,Annette Affolter,Frederic Jungbauer,Anne Lammert,Nicole Rotter,
Molecular medicine (Cambridge, Mass.)no. 1 (2023): 69-14
BIOMEDICINESno. 9 (2023): 2588-2588
Daniel Haeussler, Christopher Mayer,Angela Schell,Lena Zaubitzer, Sylvia Büttner,Deniz Gencer,Nicole Rotter,Benedikt Kramer
Laryngo-rhino-otologieno. 06 (2023): 434-439
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Laryngo-rhino-otologie (2023)
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Lena Zaubitzer,Sonja Ludwig, Michelle Berkemann, Beatrice Walter,Frederic Jungbauer,Valentin Held,Stefan C. A. Hegemann,Nicole Rotter,Angela Schell
FRONTIERS IN NEUROLOGY (2023): 1134540-1134540
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