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Nicole Gaudelli studied the structural and mechanistic underpinnings of neocarzinostatin biosynthesis and a non-heme iron oxygenase involved in vancomycin assembly. She studied monocyclic beta-lactam antibiotics and elucidated the mechanism through which they are biosynthesized. She expanded the capabilities of base editing technology by creating the first adenine base editor (ABE) through 7 rounds of directed evolution and engineering.
Dr. Gaudelli is an inventor on numerous base editing patents. Dr. Gaudelli is a recipient of the 2018 American Chemical Society’s “Talented 12” award, recognized as a 2018 STAT News Wunderkind, a 2018 TEDMED Hive honoree, Genetic Engineering and Biotechnology News “Top 10 Under 40 of 2019”, BioSpace’s 2019 “10 Life Science Innovators Under 40 to Watch”, and is MIT’s 2019 Technology Reviews’ 35 Innovators Under 35.
Dr. Gaudelli is an inventor on numerous base editing patents. Dr. Gaudelli is a recipient of the 2018 American Chemical Society’s “Talented 12” award, recognized as a 2018 STAT News Wunderkind, a 2018 TEDMED Hive honoree, Genetic Engineering and Biotechnology News “Top 10 Under 40 of 2019”, BioSpace’s 2019 “10 Life Science Innovators Under 40 to Watch”, and is MIT’s 2019 Technology Reviews’ 35 Innovators Under 35.
研究兴趣
论文共 29 篇作者统计合作学者相似作者
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Nandini Mondal,Alexander Harmon, Elizabeth Budak,Kathy Zhang,Jeffrey Wong, Archita Menon,Adam Wolin, Moriah White,Faith Musenge,Adam Camblin, Cristina Baricordi, Brent Coisman,
MOLECULAR THERAPYno. 4 (2023): 706-707
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Lam, Dieter K.,Feliciano, Patricia R.,Arif, Amena,Bohnuud, Tanggis, Fernandez, Thomas P.,Gehrke, Jason M.,Grayson, Phil, Lee, Kin D., Ortega, Manuel A., Sawyer, Courtney, Schwaegerle, Noah D., Peraro, Leila,
Nature Biotechnologyno. 5 (2023): 1-12
CURRENT OPINION IN STRUCTURAL BIOLOGY (2021): 86-98
Kiran Musunuru,Alexandra C. Chadwick,Taiji Mizoguchi,Sara P. Garcia,Jamie E. DeNizio,Caroline W. Reiss,Kui Wang,Sowmya Iyer,Chaitali Dutta, Victoria Clendaniel, Michael Amaonye, Aaron Beach,
Adrian P. Rybak, Elsie Zahr Akrawi,Conrad Rinaldi,Scott J. Haskett,Ling Lin,Jeffrey Marshall,Alexander Liquori,Luis Barrera, Jenny Olins,S. Haihua Chu,Jeremy Decker,Minerva Sanchez,
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Molecular Therapyno. 12 (2020): 2519-2520
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