Dr. Abend’s research focuses on development and implementation of innovative strategies that mitigate secondary brain injury and improve long-term neurobehavioral outcomes in critically ill children and neonates. His work addresses electroencephalographic seizure (ES) identification and management in critically ill patients and continuous electroencephalographic monitoring (CEEG) as a real-time brain function monitor, collaboration with colleagues in is Critical Care Medicine and Anesthesia, Neonatology, Surgery, Quality Improvement, Statistics, and Neuro-Engineering. Overall, his work has shown ES are common in critically ill children and neonates but usually only detectable with CEEG, high ES burden is associated with unfavorable neurodevelopmental outcomes, and ES can often be safely and effectively managed with anti-seizure medications. This work has served as the foundation for clinical pathways and management guidelines. His work also focuses on quality improvement in pediatric neurology at CHOP and nationally, guided by large-scale electronic medical record derived data analytics and implemented through electronic medical record components to help optimize physician decision making and patient care.