I am the Director of CRUK Barts Centre. My groups' primary research interests are in the genomics and molecular pathology of pancreatic cancer and the development of oncolytic virotherapy.
I work with Professor Claude Chelala and Dr Tatjana Crnogorac-Jurcevic on the genomics and molecular pathology of pancreatic cancer. We use global profiling approaches at the genomic and proteomic levels to identify targets that can be exploited for detection and treatment of this disease. We are also developing novel platforms and algorithms for the bioinformatic interrogation and interpretation of very large, multidimensional datasets.
I work with Professor Yaohe Wang and Dr Gunnel Halldén on the development of oncolytic virotherapy, an approach that uses adenoviruses and vaccinia viruses that selectively replicate within and kill cancer cells, but leave normal cells untouched. We are also working on defining the cell survival signalling circuits that determine the sensitivity of cancer cells to this approach. The role of the immune system in modulating viral replication and tumour cell destruction is the focus of a major new programme.