基本信息
浏览量:3
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
My career has been focused in research on molecular metabolism. During my Doctoral Thesis (UCM, 1988-91), I studied insulin/IGF1 actions in brown adipocytes. During my post-doctoral period at Cancer Research UK (London, 1991-93), I cloned protein kinase D1, a Ser/Thr kinase that subsequent studies revealed its key role in cancer and more recently, in glucose homeostasis. Back to Spain (1994, Assistant Prof. at UCM), I implemented my expertise in signal transduction in unraveling insulin/IGF1 signaling pathways responsible of proliferation/differentiation of brown adipocytes. From 2002 and as a CSIC Senior Scientist (Biochemistry Institute, CSIC/UCM), I explored insulin resistance/sensitivity in the liver, particularly the role of IRS2 and PTP1B, two opposite modulators of insulin action. In 2006 I moved to IIBm Alberto Sols (CSIC/UAM) where I consolidated my leadership as PI and extended my research on the molecular basis of obesity and co-morbidities with a special focus in non-alcoholic fatty liver disease. During the last 10 years I have also investigated in diabetic complications (retinopathy/nephropathy) and drug-induced insulin resistance. In the context of ITN-TREATMENT-H2020, we evaluated the impact of antipsychotics on insulin secretion by beta-cells. These research was funded by competitive national grants (BFU2005, 2008, SAF2009, 2012, 2015, RTI2018), national consortiums (MOIR-CAM, MOIR2-CAM, CIBERDdem) and international grants (EFSD 2011, 2021, MSCA-ITN-TREATMENT) in which I participated as PI.
I have collaborated with over 100 relevant national/international researchers as reflected in joint publications, participated in regional (CAM), national (ISCIII, AEI) and international (EUROCONDOR-FP7, ITN-TREATMENT-H2020) consortiums and established contracts with pharmaceutical/biotech companies (Project SL Science to Technology (Spain), Hoffman-La Roche (USA), Medimmune-Astrazeneca (USA, UK), Laboratorios Silanes SL (Mexico DC) and recently Pep2Tango Therapeutics (USA)). These collaborations have been based in testing chemical, genetic and biological tools in preclinical models for metabolic diseases and contributed to a sexenio tecnológico (2009-2014).
Scientific results have been presented in national/international meetings. I have also actively participated in activities to communicate with the general public (school visits, researcher’s night, press releases, interviews). Also, I am currently Executive Editor of the Journal of Physiology & Biochemistry, member of the Editorial Boards of BBA Molecular Basis of Disease and Scientific Reports and Member of Spanish Royal Academy of Pharmacy.
During my career I have supervised 11 Doctoral Thesis. Since 2012, I have supervised 7 Doctoral Thesis, another will be defended in January 2022 and 3 are ongoing. The doctoral fellows are now working in research (academia), industry and teaching. Just to highlight that my first PhD student holds a Científico Titular (CSIC) position. I have supervised 5 postdoctoral fellows from competitive calls (J de la Cierva, S Borrell) and one of them is now a PI (Nicolas Monardes) at Univ. of Cadiz. The others work in academia or industry. I have also supervised 3 CIBERdem postdoctoral fellows that continue working in research (academia).
I have actively participated in grant evaluation (AEI, Israel Scientific Foundation, Diabetes UK, CNRS, etc…) and I collaborated with the AEI in evaluation Committees and as coordinator FOS-BME subarea (2018-21).
研究兴趣
论文共 182 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Vítor Ferreira,Cintia Folgueira, Ángela Montes-San Lorenzo, Andrea Rodríguez-López, Eva Gonzalez-Iglesias,Pablo Zubiaur,Francisco Abad-Santos,Guadalupe Sabio,Patricia Rada,Ángela M. Valverde
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseaseno. 5 (2024)
Paula Gallardo-Villanueva,Tamara Fernandez-Marcelo, Laura Villamayor,Angela M. Valverde,Sonia Ramos,Elisa Fernandez-Millan,Maria Angeles Martin
NUTRIENTSno. 2 (2024): 273
Raquel Fernandez-Gines,Jose Antonio Encinar,Maribel Escoll, Daniel Carnicero-Senabre,Jose Jimenez-Villegas, Angel J. Garcia-Yaguee,Agueda Gonzalez-Rodriguez,Irma Garcia-Martinez,Angela M. Valverde,Ana I. Rojo,Antonio Cuadrado
REDOX BIOLOGY (2024)
FREE RADICAL BIOLOGY AND MEDICINE (2024): 448-461
Patricia Maranon,Esther Rey, Stephania C. Isaza,Hanghang Wu,Patricia Rada,Carmen Choya-Foces, Antonio Martinez-Ruiz, Maria Angeles Martin, Sonia Ramos,Carmelo Garcia-Monzon,Francisco Javier Cubero,Angela M. Valverde,
Redox Biology (2024): 103027-103027
FASEB journal : official publication of the Federation of American Societies for Experimental Biologyno. 2 (2024): e23418-e23418
Javier Jurado-Aguilar,Emma Barroso, Maribel Bernard,Meijian Zhang, Mona Peyman,Patricia Rada,Ángela M Valverde,Walter Wahli,Xavier Palomer,Manuel Vázquez-Carrera
Metabolism: clinical and experimental (2024): 155772-155772
Javier Jurado-Aguilar,Emma Barroso, Maribel Bernard,Meijian Zhang,Mona Peyman,Patricia Rada,Angela M. Valverde,Walter Wahli,Xavier Palomer,Manuel Vazquez-Carrera
Vítor Ferreira,Cintia Folgueira, Ángela Montes-San Lorenzo, Andrea Rodríguez-López, Eva Gonzalez-Iglesias,Pablo Zubiaur,Francisco Abad-Santos,Guadalupe Sabio,Patricia Rada,Ángela M. Valverde
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseaseno. 5 (2024): 167227
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn