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Research in our laboratory investigates how neurons acquire distinct identities and form precise connections in the developing cerebral cortex, a part of the brain involved in a variety of higher cognitive, emotional, sensory, and motor functions. We also study how these developmental processes have changed during evolution and in human disorders. We study these problems for primarily two reasons. The first reason is to explore what it is about our brain that makes us human. The most important distinction between humans and other species is largely thought to reside in the unique features of human brain development, especially the way in which intricate neuronal circuits of the cerebral cortex are wired. The second reason for this research is to understand why humans suffer from certain brain diseases. The emergence of intricate neuronal circuits has given us remarkable cognitive abilities, but may have also increased our susceptibility to disorders such as autism and schizophrenia.
An important element of our research is the integration of complementary approaches at the interface of developmental neurobiology, molecular biology, comparative genomics, and genetics. To achieve this, we combine:
Analyses of evolutionarily conserved developmental mechanisms using the genetically tractable mouse model
Comparative analyses to identify human-specific features of brain development
Genetic and molecular analyses of disorders of human cognitive development
Research in our laboratory investigates how neurons acquire distinct identities and form precise connections in the developing cerebral cortex, a part of the brain involved in a variety of higher cognitive, emotional, sensory, and motor functions. We also study how these developmental processes have changed during evolution and in human disorders. We study these problems for primarily two reasons. The first reason is to explore what it is about our brain that makes us human. The most important distinction between humans and other species is largely thought to reside in the unique features of human brain development, especially the way in which intricate neuronal circuits of the cerebral cortex are wired. The second reason for this research is to understand why humans suffer from certain brain diseases. The emergence of intricate neuronal circuits has given us remarkable cognitive abilities, but may have also increased our susceptibility to disorders such as autism and schizophrenia.
An important element of our research is the integration of complementary approaches at the interface of developmental neurobiology, molecular biology, comparative genomics, and genetics. To achieve this, we combine:
Analyses of evolutionarily conserved developmental mechanisms using the genetically tractable mouse model
Comparative analyses to identify human-specific features of brain development
Genetic and molecular analyses of disorders of human cognitive development
研究兴趣
论文共 208 篇作者统计合作学者相似作者
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Lee T. Kissel,Sirisha Pochareddy,Joon-Yong An,Nenad Sestan,Stephan J. Sanders, Xuran Wang,Donna M. Werling
Biological Psychiatry Global Open Sciencepp.100321, (2024)
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biorxiv(2024)
Shreyash Sonthalia, Guangyan Li, Xoel Mato Blanco,Alex Casella,Jinrui Liu, Genevieve Stein-O'Brien,Brian Caffo, Ricky S Adkins,Joshua Orvis,Ronna Hertzano,Anup Mahurkar,Jesse Gillis,
bioRxiv : the preprint server for biology (2024)
Katherine Fleck,Victor Luria, Nitanta Garag,Amir Karger, Trevor Hunter, Daniel Marten,William Phu, Kee-Myoung Nam,Nenad Sestan, Anne H O'Donnell-Luria,Jelena Erceg
bioRxiv : the preprint server for biology (2024)
Ligia Simoes Braga Boisserand, Luiz Henrique Geraldo, Jean Bouchart, Marie-Renee El Kamouh, Seyoung Lee,Basavaraju G Sanganahalli, Myriam Spajer,Shenqi Zhang,Sungwoon Lee,Maxime Parent,Yuechuan Xue,Mario Skarica,
The Journal of experimental medicineno. 4 (2024)
McKinzie A. Garrison,Yeongjun Jang,Taejeong Bae,Adriana Cherskov,Sarah B. Emery,Liana Fasching, Attila Jones,John B. Moldovan, Cindy Molitor,Sirisha Pochareddy,Mette A. Peters,Joo Heon Shin,
Scientific Datano. 1 (2023): 1-18
Cindy Wen,Michael Margolis,Rujia Dai,Pan Zhang,Pawel F Przytycki, Daniel D Vo,Arjun Bhattacharya,Nana Matoba,Chuan Jiao,Minsoo Kim, Ellen Tsai, Celine Hoh,
medRxiv (Cold Spring Harbor Laboratory) (2023)
Biological Psychiatryno. 9 (2023): S11-S12
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Nicola Micali,Shaojie Ma,Mingfeng Li,Suel-Kee Kim, Xoel Mato-Blanco, Suvimal Kumar Sindhu,Jon I. Arellano,Tianliuyun Gao,Mikihito Shibata,Kevin T. Gobeske,Alvaro Duque,Gabriel Santpere,
SCIENCEno. 6667 (2023): 171-+
medRxiv : the preprint server for health sciences (2023)
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