基本信息
浏览量:6
职业迁徙
个人简介
Nathan Skene's interests lie in using human genetics to gain insight into the neurobiology of brain disorders and cognitive traits. A core part of his work has am focused on identifying the causal cell types underlying complex genetic traits. His research groups aim to tackle basic questions about brain disorders: where they occur, at which developmental stage genetic insults take place, and the biological processes acted on within each cell type involved.
His postdoctoral research was done at the Karolinska Institutet (KI) where he worked with Jens Hjerling-Leffler as part of the Functional Neuromics project. At KI he was involved in developing large scale single cell RNA-seq atlases of brain cell types, and using these datasets to gain insight into genetic disorders. Using this approach he was able to show that multiple cell types play a role in the etiology of schizophrenia, while only microglia appear to be influenced by the common genetic factors influencing Alzheimers. He developed the EWCE and MAGMA_Celltyping R packages to facilitate these analyses.
He gained an undergraduate degree in Artificial Intelligence and Cybernetics from the University of Reading in 2008, followed by an MPhil at the University of Cambridge in Computational Biology in 2009. He went on to do a PhD in Molecular Biology at the Wellcome Trust Sanger Institute working with Prof Seth Grant. During this time he worked on the Genes to Cognition programme, analysing the transcriptomic changes seen in a mice carrying a wide range of synaptic mutations. Later, while working between the University of Edinburgh and UCL, he studied how postnatal gene expression changes influence the onset of psychiatric disorders.
His postdoctoral research was done at the Karolinska Institutet (KI) where he worked with Jens Hjerling-Leffler as part of the Functional Neuromics project. At KI he was involved in developing large scale single cell RNA-seq atlases of brain cell types, and using these datasets to gain insight into genetic disorders. Using this approach he was able to show that multiple cell types play a role in the etiology of schizophrenia, while only microglia appear to be influenced by the common genetic factors influencing Alzheimers. He developed the EWCE and MAGMA_Celltyping R packages to facilitate these analyses.
He gained an undergraduate degree in Artificial Intelligence and Cybernetics from the University of Reading in 2008, followed by an MPhil at the University of Cambridge in Computational Biology in 2009. He went on to do a PhD in Molecular Biology at the Wellcome Trust Sanger Institute working with Prof Seth Grant. During this time he worked on the Genes to Cognition programme, analysing the transcriptomic changes seen in a mice carrying a wide range of synaptic mutations. Later, while working between the University of Edinburgh and UCL, he studied how postnatal gene expression changes influence the onset of psychiatric disorders.
研究兴趣
论文共 63 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
biorxiv(2024)
Nature Communicationsno. 1 (2024): 1-10
Mariusz Mucha,Anna E. Skrzypiec, Jaison B. Kolenchery,Valentina Brambilla,Satyam Patel,Alberto Labrador-Ramos,Lucja Kudla, Kathryn Murrall,Nathan Skene,Violetta Dymicka-Piekarska,Agata Klejman,Ryszard Przewlocki,
引用2浏览0WOSNATURE引用
2
0
biorxiv(2023)
medRxiv (Cold Spring Harbor Laboratory) (2023)
Research Square (Research Square) (2023)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn