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My lab focuses on how cell-matrix adhesions and Rho family GTPases regulate epithelial polarity and morphogenesis of normal breast tissue and how these signals are subverted in breast cancer.
We are studying the mechanisms by which integrin signals guide tissue morphogenesis at three levels: First, how integrins instruct epithelial cells to polarize and form lumen spaces within tissues; second, how integrin-mediated mechanical forces engineer the morphogenetic tissue shapes of a branched epithelium and third, how integrins direct the spatial ordering of different mammary cell lineages to form the correct tissue structure.
Mammary tissue forms a network of branched ducts connected to alveoli with hollow lumens, similar to many other secretory organs. We use Cre-LoxP genetic deletion both in vivo and in primary 3D organoid cultures of mammary epithelia, to unravel the relative contribution of integrins and GTPases to mammary tissue organization and function.
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2011)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2010)
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