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The mammalian heart is a complex multi-chambered pump. The proper function of the heart requires highly coordinated process of differentiation and integration of each cellular component. Through the continuing evolutionary selection the cardiac morphogenesis process has been modified and fine tuned to eventually make the miracle of mammalian cardiogenesis. For more than three decades, researchers have been studying how artistic and miraculous this morphogenesis event is. The recent advances in forward and reverse molecular genetics have added a new dimension to the understanding of the cardiogenesis - as represented by discoveries of key transcription factors and diverse cell lineages contributing to the formation of the heart, the developmental biology of the heart has had a great progress over the past decade. However, our understanding of how a highly diverse and specialized subset of heart cell lineages arises from mesodermal precursors and subsequently is assembled into distinct muscle chambers, coronary arterial tree and large vessels, valvular tissue, and conduction system/pacemaker cells remains at a relatively primitive stage. The overall goal of our research is to understand the art of the cardiogenesis from stem cell perspective and uncover the fundamental mechanism of heart formation that cannot be answered simply by molecules and morphology. The key questions we would like to address are; (1) How the commitment and diversification of the cardiac cells is regulated at each level of cardiogenesis (2) How plastic the heart cells are and what is the biological significance of the plasticity during cardiac morphogenesis and disease development (3) What is the molecular mechanism that makes the adult cardiomyocytes terminally differentiated and unable to divide.
The mammalian heart is a complex multi-chambered pump. The proper function of the heart requires highly coordinated process of differentiation and integration of each cellular component. Through the continuing evolutionary selection the cardiac morphogenesis process has been modified and fine tuned to eventually make the miracle of mammalian cardiogenesis. For more than three decades, researchers have been studying how artistic and miraculous this morphogenesis event is. The recent advances in forward and reverse molecular genetics have added a new dimension to the understanding of the cardiogenesis - as represented by discoveries of key transcription factors and diverse cell lineages contributing to the formation of the heart, the developmental biology of the heart has had a great progress over the past decade. However, our understanding of how a highly diverse and specialized subset of heart cell lineages arises from mesodermal precursors and subsequently is assembled into distinct muscle chambers, coronary arterial tree and large vessels, valvular tissue, and conduction system/pacemaker cells remains at a relatively primitive stage. The overall goal of our research is to understand the art of the cardiogenesis from stem cell perspective and uncover the fundamental mechanism of heart formation that cannot be answered simply by molecules and morphology. The key questions we would like to address are; (1) How the commitment and diversification of the cardiac cells is regulated at each level of cardiogenesis (2) How plastic the heart cells are and what is the biological significance of the plasticity during cardiac morphogenesis and disease development (3) What is the molecular mechanism that makes the adult cardiomyocytes terminally differentiated and unable to divide.
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Adam D Langenbacher,Fei Lu, Luna Tsang, Zi Yi Stephanie Huang, Benjamin Keer, Zhiyu Tian, Alette Eide,Matteo Pellegrini,Haruko Nakano,Atsushi Nakano,Jau-Nian Chen
bioRxiv : the preprint server for biology (2023)
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Haruko Nakano, Estrelaia S. Williams,Masahiko Hoshijima,Susumu Minamisawa,Kenneth R. Chien,Gary K. Owens,Atsushi Nakano
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