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Nadia Naffakh dirige un groupe de recherche au sein de l'Unité "Génétique Moléculaire des Virus à ARN" à l'Institut Pasteur de Paris. Ses travaux portent sur les interactions entre la machinerie de transcription des virus influenza et le micro-environnement cellulaire, et font appel à des approches d'interactomique, de crible génétique et de virologie
moléculaire. L'enjeu est double : comprendre les déterminants de la virulence et du spectre d'hôte des virus influenza, et identifier de nouvelles cibles thérapeutiques.
Influenza A viruses (IAVs) are major pathogens in humans and in animals. They undergo continuous antigenic changes and interspecies transmission, and the unpredictability of their evolution creates continuous animal and public health challenges : recurring annual epidemics, frequent epizootics, and occasional pandemics.
Our research aims at understanding how the influenza virus RNA polymerase interacts and cooperates with host cell components to control the synthesis, processing, and trafficking of the viral mRNAs and genomic RNAs. These interactions represent potential targets for the development of therapeutic antiviral drugs which could be active against a wide range of IAVs and be less likely to select for resistance mutants. Also at stake is a better understanding of the mechanisms through which the viral polymerase determines the virulence and zoonotic potential of IAVs.
moléculaire. L'enjeu est double : comprendre les déterminants de la virulence et du spectre d'hôte des virus influenza, et identifier de nouvelles cibles thérapeutiques.
Influenza A viruses (IAVs) are major pathogens in humans and in animals. They undergo continuous antigenic changes and interspecies transmission, and the unpredictability of their evolution creates continuous animal and public health challenges : recurring annual epidemics, frequent epizootics, and occasional pandemics.
Our research aims at understanding how the influenza virus RNA polymerase interacts and cooperates with host cell components to control the synthesis, processing, and trafficking of the viral mRNAs and genomic RNAs. These interactions represent potential targets for the development of therapeutic antiviral drugs which could be active against a wide range of IAVs and be less likely to select for resistance mutants. Also at stake is a better understanding of the mechanisms through which the viral polymerase determines the virulence and zoonotic potential of IAVs.
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Joe McKellar, Francisco García de Gracia, Corentin Aubé,Ana Luiza Chaves Valadão,Marine Tauziet,Mary Arnaud-Arnould,Antoine Rebendenne,Aymeric Neyret,Emmanuel Labaronne,Emiliano P. Ricci,Bénédicte Delaval,Raphael Gaudin,
biorxiv(2024)
Nature Communicationsno. 1 (2024): 1-19
crossref(2024)
Jean-Baptiste Brault, Catherine Thouvenot,Magda Cannata Serio,Sylvain Paisant, Julien Fernandes, David Geny, Lydia Danglot, Adeline Mallet,Nadia Naffakh
PLOS ONEno. 1 (2024): e0292977-e0292977
Tim Krischuns,Catherine Isel, Petra Drncova,Maria Lukarska,Alexander Pflug, Sylvain Paisant,Vincent Navratil,Stephen Cusack,Nadia Naffakh
Tim Krischuns,Catherine Isel, Petra Drncová,Maria Lukarska, A. Pflug,Sylvain Paisant,Vincent Navratil,Stephen Cusack,Nadia Naffakh
PLOS Pathogensno. 1 (2023): e1011073-e1011073
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Kuang-Yu Chen,Jayaprakash Karuppusamy,Mary B O'Neill,Vaitea Opuu, Mathieu Bahin,Sophie Foulon, Pablo Ibanez,Lluis Quintana-Murci,Tatsuhiko Ozawa,Sylvie van der Werf,Philippe Nghe,Nadia Naffakh,
Virusesno. 6 (2023): 1315-1315
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