基本信息
浏览量:0
职业迁徙
个人简介
Dr. Neal Sondheimer's research focuses on the regulation of mitochondrial gene expression and the impact of mitochondrial mutations in common and rare disease.
Strong pathogenic mitochondrial mutations exist in a state of heteroplasmy, a mixture of normal and mutated genomes. This state provides opportunities for therapy, as the increase of wild type mitochondrial DNA or the suppression of mutated mitochondrial DNA could improve health. Dr. Sondheimer and his team are investigating mechanisms that could allow shifts in heteroplasmic ratios.
Dr. Sondheimer is interested in the effects of mitochondrial mutations in common diseases and phenotypes such as Alzheimer disease, aging, autism and preterm birth. Because bioenergetic capacity is critical to many parts of the body, subtle changes in mitochondrial DNA may have profound effects over time.
The mitochondrial genome is the small, densely coding, maternally inherited DNA that encodes core subunits of the electron transport chain. Many features of gene regulation are more similar to bacterial and phage systems than they are to gene regulation in the nucleus. Defects in the maintenance of mitochondrial DNA and in the translation of gene products are known causes of disease. Dr. Sondheimer and his team are investigating the dysregulation of mitochondrial transcription as another possible avenue to bioenergetic failure.
Strong pathogenic mitochondrial mutations exist in a state of heteroplasmy, a mixture of normal and mutated genomes. This state provides opportunities for therapy, as the increase of wild type mitochondrial DNA or the suppression of mutated mitochondrial DNA could improve health. Dr. Sondheimer and his team are investigating mechanisms that could allow shifts in heteroplasmic ratios.
Dr. Sondheimer is interested in the effects of mitochondrial mutations in common diseases and phenotypes such as Alzheimer disease, aging, autism and preterm birth. Because bioenergetic capacity is critical to many parts of the body, subtle changes in mitochondrial DNA may have profound effects over time.
The mitochondrial genome is the small, densely coding, maternally inherited DNA that encodes core subunits of the electron transport chain. Many features of gene regulation are more similar to bacterial and phage systems than they are to gene regulation in the nucleus. Defects in the maintenance of mitochondrial DNA and in the translation of gene products are known causes of disease. Dr. Sondheimer and his team are investigating the dysregulation of mitochondrial transcription as another possible avenue to bioenergetic failure.
研究兴趣
论文共 111 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Dwight Koeberl,Andreas Schulze,Neal Sondheimer,Gerald S. Lipshutz, Tarekegn Geberhiwot, Lerong Li,Rajnish Saini, Junxiang Luo,Vanja Sikirica, Ling Jin,Min Liang, Mary Leuchars,
Nature (2024)
Dwight Koeberl,Andreas Schulze,Neal Sondheimer,Gerald S Lipshutz,Tarekegn Geberhiwot, Lerong Li, Rajnish Saini, Junxiang Luo,Vanja Sikirica, Ling Jin,Min Liang, Mary Leuchars,
Nature (2024)
Dwight Koeberl,Andreas Schulze,Neal Sondheimer,Gerald S. Lipshutz,Tarekegn Geberhiwot, Lerong Li, Rajnish Saini, Junxiang Luo,Vanja Sikirica, Ling Jin,Min Liang, Mary Leuchars,
Naturepp.1-1, (2024)
Dwight Koeberl,Andreas Schulze,Neal Sondheimer,Gerald S. Lipshutz,Tarekegn Geberhiwot, Lerong Li, Rajnish Saini, Junxiang Luo,Vanja Sikirica, Ling Jin,Min Liang, Mary Leuchars,
Naturepp.1-6, (2024)
Darcy L Fehlings,Mehdi Zarrei,Worrawat Engchuan,Neal Sondheimer,Bhooma Thiruvahindrapuram,Jeffrey R MacDonald,Edward J Higginbotham,Ritesh Thapa, Tarannum Behlim, Sabrina Aimola,Lauren Switzer,Pamela Ng,
Nature geneticspp.1-10, (2024)
Neal Sondheimer,David Lubkowicz, Julie Blasbalg, Jillian Means, Mary McDonald,Michael James, Mylene Perrault,Caroline Kurtz, David Hava
MOLECULAR GENETICS AND METABOLISMno. 3 (2023): 94-95
EUROPEAN JOURNAL OF HUMAN GENETICS (2023): 418-419
引用0浏览0引用
0
0
Maryam Oskoui,Mehdi Zarrei,Worrawat Engchuan,Neal Sondheimer, Bhooma Thiruv, Edward Higginbotham,Ritesh Thapa,Tarannum Behlim, Sabrina Aimola,John Wei, Prakroothi Danthi, Giovanna Pellecchia,
NEUROLOGYno. 17 (2023)
引用0浏览0引用
0
0
Neal Sondheimer, Alberto Aleman,Jessie Cameron,Hernan Gonorazky,Nesrin Sabha, Paula Oliveira,Kimberly Amburgey, Azizia Wahedi, Dahai Wang,Michael Shy,James J. Dowling
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn