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职业迁徙
个人简介
My lab has made contributions to understanding the function of mitochondria. For decades, the mitochondria have been primarily viewed as biosynthetic and bioenergetic organelles generating metabolites for the production of macromolecules and ATP, respectively. We have elucidated mitochondria have a third distinct role whereby they participate in cellular signaling processes through the release of reactive oxygen species (ROS) and the metabolite L-2hydroxyglutrate (L-2HG). Our work has implicated the necessity of mitochondrial ROS as second messengers for multiple biological processes including hypoxic activation of HIF dependent gene transcription, cellular differentiation, and immune cell activation. We have also identified that mitochondria release the metabolite L-2HG, which increases histone and DNA methylation to control hematopoietic stem cell (HSC) differentiation and regulatory T cell (Treg) function, respectively. Thus, mitochondria serve as signaling organelles. In the field of cancer, our work established that mitochondrial metabolism and ROS is necessary for tumorigenesis in vivo. Previously, the prevailing idea was that increased aerobic glycolysis (i.e. Warburg effect) was the dominant metabolic reprogramming event in cancer cells. This led to our current understanding that both aerobic glycolysis and mitochondrial metabolism are essential for tumor growth. Moreover, we found that the widely used anti-diabetic drug metformin has anti-tumor effects through inhibition of mitochondrial complex I within cancer cells. Until this finding, it was believed that metformin primarily exerts its anti-cancer effects by lowering insulin levels, a known mitogen for certain cancer cells. I have published a book entitled “Navigating Metabolism” (Cold Spring Harbor Press, 2015).
研究兴趣
论文共 401 篇作者统计合作学者相似作者
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Journal of Biological Chemistryno. 3 (2024)
Biology openno. 2 (2024)
Sheila Jonnatan,Rajendra Kumar, Varsha Vakkala,Karthik Vasan, Zachary R. Chalmers,Daniel R. Schmidt, Philip A. Beer,Matthew G. Vander Heiden,Samuel R. Denmeade,Navdeep S. Chandel,Laura A. Sena
Cancer Researchno. 7_Supplement (2024)
JOURNAL OF CLINICAL INVESTIGATIONno. 3 (2024)
Aida Rashidi, Leah K. Billingham,Andrew Zolp,Tzu-yi Chia,Caylee Silvers, Joshua L. Katz,Cheol H. Park, Suzi Delay, Lauren Boland, Yuheng Geng,Steven M. Markwell,Crismita Dmello,
Umakant Sahu,Elodie Villa,Colleen R. Reczek,Zibo Zhao, Brendan P. O’Hara, Michael D. Torno, Rohan Mishra, William D. Shannon,John M. Asara,Peng Gao,Ali Shilatifard,Navdeep S. Chandel,
Scienceno. 6690 (2024): 1484-1492
Siqi Chen,Jie Fan,Ping Xie,Jihae Ahn, Michelle Fernandez,Leah K Billingham,Jason Miska, Jennifer D Wu,Derek A Wainwright,Deyu Fang, Jeffrey A Sosman,Yong Wan,
The Journal of clinical investigation (2024)
biorxiv(2024)
Amin Sobh, Elena Encinas,Alisha Patel, Greeshma Surapaneni,Charlotte Kaestner, Janai Poullard, Monica Clerio,Karthik Vasan, Tzipporah Freeman, Dongwen Lv,Daphne Dupere-Richer,Alberto Riva,
Cancer Researchno. 6_Supplement (2024): 7058-7058
Amin Sobh, Elena Encinas,Alisha Patel, Greeshma Surapaneni, Emilie Bonilla,Charlotte Kaestner, Janai Poullard, Monica Clerio,Karthik Vasan, Tzipporah Freeman, Dongwen Lv,Daphné Dupéré-Richér,
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