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Dr. Cashman’s research focus is elucidating the structure and pathogenicity of proteins which misfold in neurodegeneration, starting with the prion protein (Cell 1990). He has developed novel strategies for immunotherapeutic intervention in these diseases, which are specifically directed at peptide motifs exposed by protein misfolding, but inaccessible in native structures. This notion of targeting a propagating and toxic conformation while sparing normal proteins was pioneered by his studies of prion-specific epitopes (Nat Med 2003; Nat Rev Drug Discov 2004). With Dr. Steven Plotkin of UBC Department of Physics and Astronomy, he has also identified Aβ oligomer-specific conformational epitopes as safe targets for Alzheimer’s disease immunotherapies that spare monomers and fibrils (ACS Chem Neurosci 2018; Sci Rep 2019).
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Cristen Molzahn,Erich Kuechler,Lorenz Nierves, Gary Cole,Jing Wang,Neil Cashman, Aly Karsan,Philipp F Lange,Joerg Gsponer,Thibault Mayor
biorxiv(2024)
Medicine internationalno. 2 (2024): 11-11
Edward Pokrishevsky,Michéle G. DuVal,Luke McAlary, Sarah Louadi,Silvia Pozzi, Andrei Roman, Steven S. Plotkin,Anke Dijkstra,Jean-Pierre Julien,W. Ted Allison,Neil R. Cashman
Journal of Biological Chemistrypp.107207-107207, (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Neil Cashman,Beibei Zhao,Catherine Cowan, Ananya Saraph,Darren Christy, Juliane Coutts,Johanne Kaplan
NEUROLOGYno. 17 (2023)
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Handbook of Clinical Neurologypp.89-99, (2023)
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Proceedings of the National Academy of Sciences of the United States of Americano. 45 (2023)
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