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个人简介
Restifo is a pioneer in the field of cancer immunotherapy with a focus on the use of T cells in the treatment of malignancy. One of Dr. Restifo's major discoveries is that CD8+ T cells experience a stereotypical maturational program. His early work was focused on discovering how tumor cells can escape from T cell recognition. He went on to characterize the mechanisms underlying why T cells survive and expand better after lymphodepletion. His most recent efforts include a focus on how elements – literally from the periodic table – influence cancer immunity. These include work on how oxygen can inhibit anti-tumor immunity and how potassium ions from dying cancer cells can shut down the anti-tumor response.
Successful treatment of patients with cancer is the goal of his laboratory, and his therapeutic approaches employ adoptive T cell transfer, gene modification and cellular reprogramming. Basic aspects of tumor and T cell immunology inform novel therapeutic interventions in the clinic.
Restifo and his research team have made contributions to the fields of adoptive cell transfer tumor immune-escape, virally encoded cancer vaccines, adoptive cell transfer for the treatment of cancer, and the biology of self/tumor-reactive T cells, with an emphasis on memory CD8+ T cells.
Successful treatment of patients with cancer is the goal of his laboratory, and his therapeutic approaches employ adoptive T cell transfer, gene modification and cellular reprogramming. Basic aspects of tumor and T cell immunology inform novel therapeutic interventions in the clinic.
Restifo and his research team have made contributions to the fields of adoptive cell transfer tumor immune-escape, virally encoded cancer vaccines, adoptive cell transfer for the treatment of cancer, and the biology of self/tumor-reactive T cells, with an emphasis on memory CD8+ T cells.
研究兴趣
论文共 572 篇作者统计合作学者相似作者
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Biao Wang,Nicholas Restifo,Raul Vizcardo,Gary Lee,Kriti Bahl,Shobha Potluri, Zheng Zhong, Yin Huang,Takuya Maeda, Jessica Fioravanti,Naritaka Tamaoki, Burak Kutlu,
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
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Cancer research communicationsno. 5 (2023): 917-932
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Cell reports methodsno. 4 (2023): 100460-100460
Yogin Patel,Benjamin Harris,Melissa Bedard, Joanna Kritikou, Meritxell Galindo Casas,Carson Harms,Melissa DeFrancesco,Purnima Sundar,Nicholas Restifo,Gary Lee,Shobha Potluri,Suman Kumar Vodnala
Regular and Young Investigator Award Abstracts (2022): A389-A389
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