基本信息
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职业迁徙
个人简介
Dr. Nady El Hajj graduated in biology from the American University of Beirut in 2007 and received his PhD from the Institute of Human Genetics at the University of Würzburg in 2011. His dissertation work investigated the epigenetic risks of assisted reproductive technologies and infertility on germ cells and embryos. During his postdoctoral training at the lab of Thomas Haaf, he focused on identifying whether maternal gestational diabetes during pregnancy causes epigenetic alterations in the developing fetus. In addition, he was involved in studying paternal age effects on germ cells and the offspring of older fathers from an epigenetic perspective. In 2017, he joined Baylor College of Medicine on a fellowship supported by the German research foundation where he performed bioinformatics analysis on whole genome bisulfite sequencing data to understand interindividual DNA methylation variation in humans. His research is published in > 40 peer-reviewed articles and has been cited more than 1100 times.
Research Interests
Epigenetic information in form of histone modifications and DNA methylation has an important role in regulating gene expression. Such epigenetic changes are maintained in daughter cells after mitotic cell division. It is well known that the epigenome is highly plastic, particularly during early development and susceptible to internal genetic signals and to external environmental cues. Studies in monozygotic twins have revealed increase in DNA methylation variation during aging, which may contribute to their phenotypic discordance. A subset of sites in the genome is susceptible to age-related DNA methylation changes in somatic tissues and, to some extent, even in germ cells. The accumulation of stochastic and environmentally induced epigenetic changes over time may contribute significantly to the age-related manifestation of complex disease.
Study DNA methylation and expression changes in the premature aging disorder Werner Syndrome
Determine the effect of paternal aging on epimutations and de novo mutations in germ cells, and how they might contribute to increased disease risk in offspring of older fathers
Establishing single nucleus RNA-seq and DNA methylation methodologies to determine the effect of aging on gene expression and DNA methylation within myotube nuclei
HONORS AND AWARDS
2012; Young Investigator Award for Outstanding Science; European Society of Human Genetics; Nürnberg/Germany
Research Interests
Epigenetic information in form of histone modifications and DNA methylation has an important role in regulating gene expression. Such epigenetic changes are maintained in daughter cells after mitotic cell division. It is well known that the epigenome is highly plastic, particularly during early development and susceptible to internal genetic signals and to external environmental cues. Studies in monozygotic twins have revealed increase in DNA methylation variation during aging, which may contribute to their phenotypic discordance. A subset of sites in the genome is susceptible to age-related DNA methylation changes in somatic tissues and, to some extent, even in germ cells. The accumulation of stochastic and environmentally induced epigenetic changes over time may contribute significantly to the age-related manifestation of complex disease.
Study DNA methylation and expression changes in the premature aging disorder Werner Syndrome
Determine the effect of paternal aging on epimutations and de novo mutations in germ cells, and how they might contribute to increased disease risk in offspring of older fathers
Establishing single nucleus RNA-seq and DNA methylation methodologies to determine the effect of aging on gene expression and DNA methylation within myotube nuclei
HONORS AND AWARDS
2012; Young Investigator Award for Outstanding Science; European Society of Human Genetics; Nürnberg/Germany
研究兴趣
论文共 77 篇作者统计合作学者相似作者
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Yosra Bejaoui,Sara Alresheq,Sophie Durand, Marie Vilaire-Meunier,Louise Maillebouis,Ayman Al Haj Zen,André Mégarbané,Nady El Hajj
Frontiers in oncology (2023): 1203483
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Epigeneticsno. 1 (2023): 2229203
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Agingno. 15 (2023): 7336-7337
Yosra Bejaoui, Fathima Humaira Amanullah,Mohamad Saad,Sara Taleb,Martina Bradic,Andre Megarbane,Ali Ait Hssain,Charbel Abi Khalil,Nady El Hajj
Clinical Epigeneticsno. 1 (2023): 186-186
Cybel Mehawej,Eliane Chouery, Ghada Al Hage Chehade,Yosra Bejaoui,Daniel Mahfoud,Maya Gerges,Valerie Delague,Nady El Hajj,Andre Megarbane
MOLECULAR SYNDROMOLOGYno. 3 (2023): 219-224
HUMAN MOLECULAR GENETICSno. 11 (2023): 1826-1835
Informatics in Medicine Unlocked (2022): 101079-101079
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