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My research interests are concerned with understanding the functional organization, and regulation of fast (amino acid) and slow (peptide) transmitter systems to better understand cell - cell communication in the nervous system. Investigations have mainly used the retina as a model to evaluate these transmitter systems. In particular, my research interests are focused on evaluating the morphological and neurochemical organization of the inner retina, and amacrine and bipolar cell populations, which are major retinal cell types that play critical roles in the processing of visual information. Recent investigations concerned with peptide-containing cell populations are defining the cellular expression patterns of tachykinin, somatostatin and opiate peptide receptors. These studies have shown that peptide receptor subtypes are selectively expressed by different populations of bipolar, amacrine and ganglion cells. These observations have provided important clues to the organization of the retinal microcircuits mediating different aspects of vision, as well as the sites of action of several previously identified retinal transmitter substances. Significant efforts are also focused on the identification and characterization of GABAergic cell types and their sites of action in the retina with specific antibodies to GABA, to the GABA synthetic enzymes, and to individual subunits of the GABAA receptor complex. Finally, to determine the sites of synaptic inactivation of GABA, the cellular localization of GABA uptake sites is being determined using novel cDNA probes and antibodies to the GABA plasma membrane transporters, GAT-1, GAT-2, GAT-3 and BGT. Overall, these studies have demonstrated the presence of distinct neurochemically identified bipolar, amacrine and ganglion cell populations. These observations indicate that different amacrine, bipolar and ganglion cell populations form defined retinal microcircuits, and play unique roles in the processing of visual information.
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Research square (2023)
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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Luis Perez de Sevilla Muller, Brandy S. Recio, Zachary Myers,Sachin Parikh, Rajesh Kumar Goit,Nicholas Brecha,Anna Matynia
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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Neuronno. 1 (2020): 111-127.e6
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