Oxidative stress is determined to be involved in various human disorders such as liver fibrosis, kidneys dysfunction, atherosclerosis, aging, cataract, cancer and arthritis. Locally used weeds and foods are considered the important wealth of the country to explore for their antioxidant activities. My research group is actively involved in the evaluation of pharmacological properties of the herbals. A number of animal models including carbon tetrachloride, potassium bromate, diclofenac and paracetamol have revealed the antioxidative potential of various fractions and extracts of different weeds. Isolation of various bioactive compounds is highly imperative in these studies in order to determine the potential pharmacological properties.